6392-01-4

Usage

Uses

Used in Medicinal Chemistry:
(4-methoxyphenyl)(morpholin-4-yl)methanethione is used as a compound of interest for medicinal chemistry due to its potential interactions with biological targets and the presence of both methoxyphenyl and morpholin-4-ylmethyl groups.
Used in Drug Development:
(4-methoxyphenyl)(morpholin-4-yl)methanethione is used as a candidate in drug development for its potential biological activities, which may include antibacterial, antifungal, and antiviral properties, given the general properties of thioamides.
While the specific applications and uses of (4-methoxyphenyl)(morpholin-4-yl)methanethione are not well-documented, its structural features and the properties of thioamides suggest that it may have potential in various industries, particularly in the development of new pharmaceuticals and treatments. Further research and investigation are needed to explore its full potential and possible applications.

Upstream product

• 110-91-8 morpholine 
• 123-11-5 4-methoxy-benzaldehyde 
• 2227-79-4 benzenecarbothioamide 
• 162274-52-4 4-<(Diphenylphosphinoyl)(4-methoxyphenyl)methyl>morpholine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 3717-21-3 p-methoxyl benzaldoxime 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 6258-60-2 p-methoxybenzylmercaptan 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 1696-20-4 4-acetylmorpholine 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 862873-20-9 4-(1H-imidazol-1-ylcarbonothioyl)morpholine 

Downstream Products

• 6392-05-8 4-[(4-methoxy-phenyl)-methylsulfanyl-methylene]-morpholinium; iodide 
• 1671-76-7 p-Methoxyvalerophenon 
• 111097-41-7 4-[1-(4-methoxyphenyl)pentyl]morpholine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 120290-10-0 4-[Ethylsulfanyl-(4-methoxy-phenyl)-methylene]-morpholin-4-ium; iodide 
• 111509-93-4 2-Cyano-3-(4-methoxyphenyl)-3-morpholinoacrylonitrile 
• 7504-58-7 N-(4-methoxybenzoyl)morpholine 
• 123-11-5 4-methoxy-benzaldehyde 
• 5925-72-4 methyl (4-methoxyphenyl)methanethionate 
• 70227-33-7 4-[ethylsulfanyl-(4-methoxy-phenyl)-methyl]-morpholine 
• 120290-16-6 4-[(4-Methoxy-phenyl)-methylsulfanyl-methyl]-morpholine 

Relevant academic research and scientific papers

Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives

A Ni-catalyzed cross-coupling of readily accessible O-alkyl xanthate esters or thiocarbonyl imidazolides and organozinc reagents for the synthesis of thiocarboxylic acid derivatives has been developed. This method benefits from a fast reaction time, mild reaction conditions, and ease of starting material synthesis. The use of transition-metal catalysis to access a diverse range of thiocarbonyl-containing compounds provides a useful complementary approach when compared with previously established methodologies.

Metal-free three-component synthesis of thioamides from β-nitrostyrenes, amines and elemental sulfur

A metal-free C[dbnd]C bond cleavage reaction of β-nitrostyrenes in the presence of elemental sulfur and secondary amines/amides is described. Elemental sulfur serves as both a raw material and an oxidant for C[dbnd]C bond cleavage, and secondary amines or amides are both feasible nitrogen sources. Besides mild reaction condition and simple work-up procedure, the method provided thioamides with good to excellent yields.

Mixed bases mediated synthesis of thioamides in water

A mixed bases mediated protocol is developed to synthesize thioamides from N-aryl or N-alkylamide, aldehyde and elemental sulfur in water. This reaction requires no addition of external oxidant and avoids large excess of amides. Various functional groups

Method for promoting elemental sulfur to synthesize thioamide by mixed alkali in water phase

The invention provides a method for promoting elemental sulfur to synthesize a thioamide compound by a mixed alkali in a water phase, and belongs to the field of organic synthesis. According to the method, an aldehyde compound and an amide compound are us

Willgerodt-Kindler reaction at room temperature: Synthesis of thioamides from aromatic aldehydes and cyclic secondary amines

A simple method for the synthesis of thioamide derivatives in DMSO at room temperature and at 120 °C has been developed. Total 27 compounds were prepared under both conditions via a one-pot, three component reaction between substituted aromatic aldehydes,

Transition-Metal-Free Cleavage of C-C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides

A novel transition-metal-free cleavage reaction of C-C triple bonds in aromatic alkynes with S8 and amides furnishes aryl thioamides in moderate to excellent yields. The remarkable features of this thioamidation include the metal-free cleavage of C-C triple bond, mild reaction conditions, as well as wide substrate scope that is particularly compatible with some internal aromatic alkynes and acetamides.

Sulfated polyborate catalyzed Kindler reaction: a rapid, efficient, and green protocol

A rapid, green, and efficient one-pot, three-component Kindler reaction was developed using a sulfated polyborate catalyst. The method described the reaction of aldehydes, amines/ammonium acetate, and sulfur for the synthesis of thioamides using sulfated polyborate under a solvent free condition at 100?°C. The key features of the present protocol are high yields, short reaction time, easy workup, and recyclability of a catalyst which gives economical as well as ecological rewards. The present method also has an ability to tolerate a variety of functional groups. Graphical abstract: [Figure not available: see fulltext.].

Thiol as a synthon for preparing thiocarbonyl: Aerobic oxidation of thiols for the synthesis of thioamides

It is a constant challenge to develop an environmentally friendly, atom-economical, and step-economical method for the preparation of thioamides. Herein, we describe an oxidation method that affords the direct conversion of thiols to thioamides without the use of exogenous sulfur reagents. This is the first instance of a successful utilization of thiols as a synthon for the preparation of thioamides under economical conditions.