64107-57-9

Basic information

• Product Name: 2-[(2-{[(3-bromopyridin-2-yl)methyl]sulfanyl}ethyl)amino]-5-(pyridin-2-ylmethyl)pyrimidin-4(3H)-one trihydrobromide
• CAS NO: 64107-57-9
• Molecular Formula: C₁₈H₂₁Br₄N₅OS
• Molecular Weight: 675.0732
• Mol File: 64107-57-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 641.1°C at 760 mmHg
• Flash Point: 341.5°C
• Vapor Pressure: 6.8E-17mmHg at 25°C
• CAS DataBase Reference: 2-[(2-{[(3-bromopyridin-2-yl)methyl]sulfanyl}ethyl)amino]-5-(pyridin-2-ylmethyl)pyrimidin-4(3H)-one trihydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-{[(3-bromopyridin-2-yl)methyl]sulfanyl}ethyl)amino]-5-(pyridin-2-ylmethyl)pyrimidin-4(3H)-one trihydrobromide(64107-57-9)
• EPA Substance Registry System: 2-[(2-{[(3-bromopyridin-2-yl)methyl]sulfanyl}ethyl)amino]-5-(pyridin-2-ylmethyl)pyrimidin-4(3H)-one trihydrobromide(64107-57-9)

Safety Data

• Hazardous Substances Data: 64107-57-9(Hazardous Substances Data)

Upstream product

• 55485-08-0 2-(2-aminoethyl)thiomethyl-3-bromopyridine 
• 122945-84-0 2-Methylsulfanyl-5-pyridin-2-ylmethyl-1H-pyrimidin-4-one; hydriodide 
• 1121-60-4 pyridine-2-carbaldehyde 
• 7340-22-9 3-pyridin-2-yl-acrylic acid 
• 2739-74-4 ethyl 3-(2-pyridinyl)propanoate 
• 64107-51-3 5-pyridin-2-ylmethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 7340-23-0 (E)-ethyl 3-(2-pyridyl)-propenoate 

Relevant articles and documents

Isocytosine H2-receptor histamine antagonists II. Synthesis and evaluation of biological activity at histamine H1- and H2-receptors of 5-(heterocyclyl)methylisocytosines

A series of 2--4-pyrimidones was synthesized based on oxmetidine 2, in which the methylenedioxyphenyl group of 2 was replaced by a heterocyclic ring.Good H2-receptor antagonist activity was retained over a range of basic and neutral heterocyclic substituents.Replacement of the 5-methyl-4-imidazolyl ring in selected compounds with 2-thiazolyl and, particularly, 3-bromo-2-pyridyl rings gave a series of compounds which have both H1- and H2-receptor histamine antagonist activities.Some structure-activity and structure-toxicity correlations are discussed.Compound 6d, 2--5-(6-methylpyrid-3-yl)-4-pyrimidone, has the most favourable combination of properties for H2-antagonism and has been evaluated further as an anti-secretory agent.