6437-85-0

Basic information

• Product Name: 3-PHENOXY-2-BUTANONE
• Synonyms: 3-PHENOXY-2-BUTANONE
• CAS NO: 6437-85-0
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 6437-85-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 46°C 0,1mm
• Flash Point: 96°C
• Appearance: /
• Density: 1.023g/cm³
• Vapor Pressure: 0.0362mmHg at 25°C
• Refractive Index: 1.495
• CAS DataBase Reference: 3-PHENOXY-2-BUTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENOXY-2-BUTANONE(6437-85-0)
• EPA Substance Registry System: 3-PHENOXY-2-BUTANONE(6437-85-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 6437-85-0(Hazardous Substances Data)

Usage

General Description

3-PHENOXY-2-BUTANONE, also known as P-box, is a synthetic organic compound with the chemical formula C10H12O2. It is a clear liquid with a sweet, floral odor and is commonly used as a fragrance ingredient in perfumes and cosmetics. It is also used as a flavoring agent in the food industry. 3-PHENOXY-2-BUTANONE is considered to be safe for use in these applications, and it is generally recognized as safe by the Food and Drug Administration. It is important to handle this chemical with caution, as it can cause irritation to the skin and eyes and should be handled in a well-ventilated area.

InChI:InChI=1/C10H12O2/c1-8(11)9(2)12-10-6-4-3-5-7-10/h3-7,9H,1-2H3/t9-/m1/s1

Upstream product

• 139-02-6 sodium phenoxide 
• 4091-39-8 3-chloro-2-butanone 
• 108-95-2 phenol 
• 122-35-0 2-phenoxypropanoic acid chloride 
• 940-31-8 2-phenoxypropionic acid 
• 917-54-4 methyllithium 
• 61628-46-4 (2-chloromethyl-3-methyl-oxiranyl)-trimethyl-silane 
• 78-93-3 butanone 
• 814-75-5 3-bromo-butanone 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 1382784-58-8 (rac)-2-(1-phenoxy-ethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one 
• 1382784-60-2 5-(4-fluorophenyl)-2-(1-phenoxyethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one 
• 1382785-93-4 (rac)-5-(1-phenoxy-ethyl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 1382785-92-3 (rac)-2,4-dioxo-5-phenoxy-hexanoic acid ethyl ester 
• 118711-23-2 (2S,3R)-(-)-3-phenoxybutan-2-ol 
• 134703-29-0 3-phenoxybutan-2-ol 
• 6437-84-9 1,2-dimethyl-2-phenoxyethylamine 
• 940-31-8 2-phenoxypropionic acid 
• 3782-00-1 2,3-dimethylbenzofuran 

Relevant articles and documents

Rhodium-Catalyzed Intermolecular Cyclopropanation of Benzofurans, Indoles, and Alkenes via Cyclopropene Ring Opening

The generation of metal carbenoids via ring opening of cyclopropenes by transition metals offers a simple entry into highly reactive intermediates. Herein, we describe a diastereoselective intermolecular rhodium-catalyzed cyclopropanation of heterocycles and alkenes using cyclopropenes as carbene precursors with a low loading of a commercially available rhodium catalyst. The reported method is scalable and could be performed with catalyst loadings as low as 0.2 mol %, with no impact to the reaction yield or selectivity.

TBAI/TBHP mediated oxidative cross coupling of ketones with phenols and carboxylic acids: Direct access to benzofurans

TBAI/TBHP mediated oxidative cross coupling of phenols and carboxylic acids with ketones has been reported under metal-free, base free, solvent free conditions enabling environmentally benign synthesis of aryloxyketones, acyloxy ketones and benzofurans. Phenoxyketones and acyloxylcarbonyl compounds were synthesized in good to high yields, where as benzofurans were synthesized in moderate yields. This method is operationally simple, works under mild conditions, using commercially available as well as inexpensive TBAI and an oxidant TBHP.

Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death

Chagas disease, caused by Trypanosoma cruzi, is a life-threatening infection leading to approximately 12,000 deaths per year. T. cruzi is susceptible to thiosemicarbazones, making this class of compounds appealing for drug development. Previously, the hom