6443-79-4Relevant articles and documents
Synthesis method of alkenyl nitrile
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Paragraph 0029-0034, (2021/11/10)
The invention discloses a synthesis method of alkenyl nitrile, which comprises the steps of: weighing a rhodium catalyst and a phosphine ligand according to a ratio, placing the rhodium catalyst and the phosphine ligand into a kettle, adding a solvent to dissolve the rhodium catalyst and the phosphine ligand, adding a nitrile compound, olefin or alkyne and an alkali, filling the reaction kettle with CO and H2, heating for a reaction, and obtaining an alkenyl nitrile compound through a hydroformylation reaction and a Knoevenagel reaction mechanism. The nitrile substrate range is wide. A good effect can be achieved no matter whether para-position and meta-position substituent groups of aryl in phenylacetonitrile are electron withdrawing groups or electron donating groups. The method can also be achieved by replacing aryl with a heterocyclic ring. The method has the advantages of mild reaction conditions, simple operation and easily available raw materials, the substrate is wide in source and can be converted into a plurality of other useful molecules, and the method is of high practicability.
[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: A synthetic route to multi-substituted 2-aminopyridines
Xin, Xiaoqing,Huang, Peng,Xiang, Dexuan,Zhang, Rui,Zhao, Fengyu,Zhang, Ning,Dong, Dewen
, p. 1001 - 1006 (2013/02/26)
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves
