6443-79-4Relevant academic research and scientific papers
Synthesis method of alkenyl nitrile
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Paragraph 0029-0034, (2021/11/10)
The invention discloses a synthesis method of alkenyl nitrile, which comprises the steps of: weighing a rhodium catalyst and a phosphine ligand according to a ratio, placing the rhodium catalyst and the phosphine ligand into a kettle, adding a solvent to dissolve the rhodium catalyst and the phosphine ligand, adding a nitrile compound, olefin or alkyne and an alkali, filling the reaction kettle with CO and H2, heating for a reaction, and obtaining an alkenyl nitrile compound through a hydroformylation reaction and a Knoevenagel reaction mechanism. The nitrile substrate range is wide. A good effect can be achieved no matter whether para-position and meta-position substituent groups of aryl in phenylacetonitrile are electron withdrawing groups or electron donating groups. The method can also be achieved by replacing aryl with a heterocyclic ring. The method has the advantages of mild reaction conditions, simple operation and easily available raw materials, the substrate is wide in source and can be converted into a plurality of other useful molecules, and the method is of high practicability.
1, 3-conjugated diene compound and preparation method and application thereof
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Paragraph 0277-0281, (2019/06/27)
The invention discloses a 1, 3-conjugated diene compound and a preparation method and application thereof. The invention provides a preparation method of the 1, 3-conjugated diene compound. The preparation method comprises the following steps: in an organic solvent and in the presence of a palladium catalyst, a phosphine ligand and an alkaline reagent, carrying out 1, 4-Pd migration/suzuki coupling reaction on an aromatic halide containing structural fragment shown in formula I and an alkenyl boron compound containing the structural fragment shown in formula II to obtain the compound containing a structural fragment of the 1, 3-conjugated diene shown in formula III. The preparation method has higher stereoselectivity and product configuration uniformity; a substrate has good universality,and is compatible with electron-deficient olefins, electron-rich olefins and polysubstituted olefins; and the method has the characteristics of mild reaction conditions, wide functional group compatibility and the like. The 1, 3-butadiene compound provided by the invention has high aggregation induced luminescence effect.
[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: A synthetic route to multi-substituted 2-aminopyridines
Xin, Xiaoqing,Huang, Peng,Xiang, Dexuan,Zhang, Rui,Zhao, Fengyu,Zhang, Ning,Dong, Dewen
, p. 1001 - 1006 (2013/02/26)
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves
Generation and reaction of ammonium ylides in basic two-phase systems
Kowalkowska, Anna,Sucholbiak, Dorota,Jonczyk, Andrzej
, p. 925 - 933 (2007/10/03)
Reaction of the quaternary ammonium salts 2a-i with electrophilic alkenes 3, active alkylating agents 7 or aromatic aldehydes 11, carried out in basic two-phase systems A-D, afforded cyclopropanes 4, cyanoalkenes 8 or cyanooxiranes 12 respectively, via the corresponding ammonium ylides 2+-. The method is very simple, and gives cyclopropanes 4 and cyanoalkenes 8 in high yield. Under similar conditions, 1-cyanodienes 8aa,ba were cyclopropanated at the γ,δ-double bond with formation of vinylcyclopropanes 9a,b. The stereochemistry of the prepared cyclopropanes was elucidated from literature, 1H NMR spectroscopic data, NOE experiments or X-ray single crystal analysis. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
