6462-29-9

Upstream product

• 558-25-8 methyl fluorosulfonate 
• 106-42-3 para-xylene 
• 124-63-0 methanesulfonyl chloride 
• 7143-01-3 Methanesulfonic anhydride 
• 66623-67-4 2,5-dimethylthioanisole 
• 75-75-2 methanesulfonic acid 
• 19040-62-1 2,5-dimethylbenzenesulfonyl chloride 
• 74-88-4 methyl iodide 

Downstream Products

• 923002-01-1 1-(2,5-dimethylphenylsulfonyl)-5-hexen-2-one 
• 923001-93-8 (1R,5R)-1-(2,5-dimethylphenylsulfonyl)bicyclo[3.1.0]hexan-2-one 
• 923001-85-8 1-diazo-1-(2,5-dimethylphenylsulfonyl)-5-hexen-2-one 

Relevant academic research and scientific papers

Sulfur(VI) fluoride compounds and methods for the preparation thereof

This application describes a compound represented by Formula (I): (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

Kinetic investigation on the highly efficient and selective oxidation of sulfides to sulfoxides and sulfones with t-BuOOH catalyzed by La2O3

The selective oxidation of various sulfides to sulfoxides by a simple, efficient, and environmentally benign method is of prime focus. In this paper, we have explored a highly efficient protocol for the oxidation of alkyl aryl sulfides to sulfoxides with high selectivities catalyzed by La2O3 in the presence of 70% t-BuOOH solution (water). We obtained predominantly the monooxygenated product. The over oxidation of sulfides to sulfones was not observed under these conditions. The resulting products are obtained in good to excellent yields within a reasonable time without the use of ligands and other additives. The epoxidation of the double bond as well as allylic oxidation are not observed with allyl sulfides. Sulfones can be obtained quantitatively by altering the reaction conditions. The surface morphology and the catalyst reusability were verified by XRD, AFM and SEM techniques. The surface area of the La2O3 was measured using BET isotherms.

Polystyrene supported Al(OTf)3: A stable, efficient, selective, and reusable catalyst for sulfonylation of arenes with sulfonic acids

Cross-linked polystyrene supported aluminium triflate (Ps-Al(OTf) 3) was found to be an efficient and chemoselective heterogeneous Lewis acid catalyst for the direct conversion of arenes to sulfones using sulfonic acids as sulfonylating agents. The solid acid catalyst is stable (as a bench top catalyst) and can be easily recovered and reused without appreciable change in its efficiency.

Direct sulfonylation of aromatic rings with aryl or alkyl sulfonic acid using supported P2O5/Al2O3

Direct sulfonylation of aromatic rings with aryl or alkyl sulfonic acid supported P2O5/Al2O3 (w/w 50%) under heterogeneous conditions in short reaction time and high yields. Copyright Taylor & Francis Inc.

Total Synergistic effect between triflic acid and bismuth(IIIr antimony(III) chlorides in catalysis of the Methanesulfonylation of Arenes

A total synergistic effect between bismuth(III) or antimony(III) chlorides and triflic acid has been observed in the Friedel-Crafts methanesulfonylation of arenes and has resulted in the development of the first efficient catalytic systems usable for the methanesulfonylation of both activated and deactivated arenes. A proposed mechanism to explain the observed effects is also discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Fe-pillared bentonite-an efficient catalyst for sulfonylation of arenes using aryl and alkyl sulfonyl chlorides

Fe-pillared bentonite (Fe-PILC) was shown to be an extremely efficient catalyst for the sulfonylation of activated as well as unactivated carbocyclic aromatic compounds and heterocyclic aromatic compounds. The catalyst was also found to be recyclable.

Nafion-H catalysed sulfonylation of aromatics with arene/alkenesulfonic acids for the preparation of sulfones

Synthesis of both symmetric and unsymmetric diaryl/aryl alkyl sulfones is easily achieved by Friedel-Crafts type sulfonylation of aromatics with suitable arene- or alkanesulfonic acids in the presence of Nafion-H, a perfluorinated resinsulfonic acid catalyst.

Friedel-Crafts sulfonylation of aromatics catalysed by solid acids: An eco-friendly route for sulfone synthesis

A mild and efficient catalytic method for Friedel-Crafts sulfonylation of arenes to the corresponding sulfones using a catalytic amount of reusable solid acid and arene- or alkanesulfonyl chlorides, sulfonic anhydrides and sulfonic acids as sulfonylating agents is described. Solid acids enable formation of a sulfone by the reaction of a sulfonic acid and an arene for the first time. In pursuit of the development of the best catalytic system, various metal-exchanged K10 montmorillonites and synthetic zeolites such as zeolite beta, zeolite Y and ZSM-5 have been screened for Friedel-Crafts sulfone synthesis. Fe3+-montmorillonite in the family of clays and zeolite beta in the family of zeolites exhibit higher activity. The activity is correlated to the presence of the right mix of Bronsted and Lewis acidic sites. The regioselective sulfonylation of toluene and naphthalene are studied in which para and beta selectivities are observed respectively. The Royal Society of Chemistry 2000.

Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones

The present invention provides a process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones. The process comprises reacting an aryl compound with an alkyl sulfonyl fluoride or with a vinyl sulfonyl fluoride in the presence of a catalyst selected from AlCl3 and AlBr3. The aryl compound is preferably selected from chlorobenzene, the isomeric xylenes, the isomeric trimethyl benzenes, and mixtures thereof. The alkyl group of the alkyl sulfonyl fluoride preferably contains 1-18 carbon atoms, and the vinyl group of the vinyl sulfonyl fluoride is unsubstituted or substituted with one or more alkyl groups containing 1-5 carbon atoms. The reaction is conducted at a temperature between about -25° C. and 150° C. in the presence or absence of an inert solvent.