64858-28-2Relevant academic research and scientific papers
Catalytic Direct Cyanomethylenation of C(sp3)–H Bonds via a One-Step Double C–C Bond Formation
Bhadra, Sukalyan,Kumar, Jogendra,Singh, Anupam Kumar
supporting information, p. 1512 - 1517 (2022/01/27)
An elegant and catalytic procedure for the one-step cyanomethylenation of C(sp3)–H bonds adjacent to benzazoles and ketones is described herein using DMF as a C-1 unit and TMSCN as the cyanide source. The copper-mediated reaction between DMF an
Highly efficient asymmetric hydrogenation of cyano-substituted acrylate esters for synthesis of chiral γ-lactams and amino acids
Kong, Duanyang,Li, Meina,Wang, Rui,Zi, Guofu,Hou, Guohua
, p. 1216 - 1220 (2016/02/03)
A highly efficient and enantioselective synthesis of γ-lactams and γ-amino acids by Rh-catalyzed asymmetric hydrogenation has been developed. Using the Rh-(S,S)-f-spiroPhos complex, under mild conditions a wide range of 3-cyano acrylate esters including both E and Z-isomers and β-cyano-α-aryl-α,β-unsaturated ketones were first hydrogenated with excellent enantioselectivities (up to 98% ee) and high turnover numbers (TON up to 10 000).
Nitrone cycloadditions to 1,2-diphenylcyclopropenes and subsequent transformations of the isoxazolidine cycloadducts
Diev, Vyacheslav V.,Stetsenko, Oksana N.,Tung, Tran Q.,Kopf, Juergen,Kostikov, Rafael R.,Molchanov, Alexander P.
, p. 2396 - 2399 (2008/09/18)
(Chemical Equation Presented) 1,3-Dipolar cycloaddition of C-aryl,N-aryl (or N-methyl) nitrones with a number of 1,2-diphenylcyclopropenes substituted at the C3 position occurs with the formation of expected "normal" cycloadducts (with N-methylnitrones) and products of their subsequent transformations. Among them are corresponding α-acetophenyl aziridines and tetra (or penta) -arylpyrroles. Aziridines and the normal cycloadducts can be also thermally converted to such arylpyrroles with moderate to good yields. Substitution at the C3 position of cyclopropenes by an electron acceptor group decreases the reactivity of cyclopropenes.
