Synthesis and evaluation of cis-hexahydropyrrolo[3,2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases

DOI: 10.1016/j.bmc.2004.10.060

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Bioorganic and Medicinal Chemistry p. 609 - 625 (2005)

Update date:2022-08-05

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Authors:

Quibell, Martin

Benn, Alex

Flinn, Nick

Monk, Tracy

Ramjee, Manoj

Ray, Peter

Wang, Yikang

Watts, John

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Article abstract of DOI:10.1016/j.bmc.2004.10.060

A stereoselective synthesis of functionalised cis-hexahydropyrrolo[3,2-b] pyrrol-3-ones has been developed through Fmoc and Cbz-protected intermediates 5 and 6. Building blocks 5 and 6 were prepared via the intramolecular cyclisation of anti-epoxide 17. T

Full text of DOI:10.1016/j.bmc.2004.10.060

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Product name:1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester, (2R)-

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