65147-89-9

Usage

Uses

Used in Pharmaceutical Synthesis:
6-BROMO-2-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological activity and unique molecular structure. It serves as a building block in the development of drug candidates that target a range of therapeutic areas, contributing to the discovery of novel treatments and medications.
Used in Organic Synthesis:
In the field of organic synthesis, 6-BROMO-2-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE is employed as a reagent due to its distinctive molecular structure and functional groups. It facilitates the creation of new organic compounds and contributes to the advancement of chemical research and development.
Used in Medicinal Chemistry Research:
6-BROMO-2-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE is utilized in medicinal chemistry research as a reagent to explore its potential applications in drug discovery. Its unique properties and structure make it a valuable tool for investigating new therapeutic agents and understanding the underlying mechanisms of action.
Used in Chemical Compound Development:
6-BROMO-2-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE is also used in the development of new chemical compounds, where its heterocyclic nature and functional groups can be leveraged to create innovative molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C12H8BrN3/c13-9-6-10-12(14-7-9)16-11(15-10)8-4-2-1-3-5-8/h1-7H,(H,14,15,16)

Upstream product

• 38875-53-5 5-bromo-pyridine-2,3-diamine 
• 100-52-7 benzaldehyde 
• 495-40-9 propiophenone 
• 98-86-2 acetophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 65-85-0 benzoic acid 
• 352672-60-7 5-bromo-N³-(phenylmethylene)pyridine-2,3-diamine 

Downstream Products

• 537025-12-0 2,6-diphenyl-1H-imidazo[4,5-b]pyridine 
• 537025-27-7 6-(2-furyl)-2-phenyl-1H-imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

Unambiguous structural assignment of monoanils obtained from 2,3-pyridinediamines

The reaction of 2,3-pyridinediamine la and its 5-bromo analogue lb independently with aromatic aldehydes results in the formation of 2-amino-and 5-bromo-2-amino-3-arylideneaminopyridines (2a and 2b) respectively. The structure of 2 has been confirmed by single crystal X-ray analysis, thereby ruling out the alternate structure for these compounds.

BICYCLIC DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a heterocyclic compound having potent tyrosine kinase-inhibiting activity represented by formula: (wherein, R1b is a C6-10 aryl group which has substituent(s), and the like; Ta is a single bond, a C1-6 alkyl group, -CH2O-, and the like; X and Y are the same or different, and each is a nitrogen atom which may have substituent(s), and the like; the broken line is a single bond or a double bond; Za is a nitrogen atom or CH; W is a single bond, an oxygen atom, and the like; Q is a C6-10 aryl group which may have substituent(s) or an aromatic heterocyclic group which may have substituent(s)); or a salt thereof and a pharmaceutical composition comprising thereof.

Structure and reactions of monoanils obtained from 2,3-pyridinediamines

The reaction of 2,3-pyridinediamines 1 with aromatic aldehydes results in the formation of 2-amino-3-arylideneaminopyridines 2 respectively. Dehydrogenative cyclisation of 2 with different reagents give 2-aryl-1H-imidazo[4,5-b]pyridines 4. Reactions of 2 with different reagents have been described.

Heterocyclisation via Selective Elimination: Reaction of 2,3-Diaminopyridine with Acyclic Ketones under Thermal Conditions

Reactions of 2,3-diaminopyridine and its 5-bromo analogue with three symmetrical and nine unsymmetrical acyclic ketones under thermal conditions have been studied.The reactions have yielded 2-substituted-1H-imidazopyridines by the elimination of one of the C2-substituents from the probable, though unisolated, intermediates 2,2-disubstituted-2,3-dihydro-1H-imidazopyridine derivatives.Elimination of one of the groups in the case of symmetrical ketones and preferentially of benzyl group in the case of benzyl methyl ketone has been observed.All the three alkyl phenyl ketones studied afford 2-phenylimidazopyridine by the selective loss of the alkyl group.Elimination of branched alkyl group has been noticed in the reactions involving methyl t-butyl and methyl i-propyl ketones, while the preferential elimination of methyl group is observed in the case of methyl n-alkyl ketones.Suitable explanations have been offered for the observed selective eliminations.