65182-98-1

Basic information

• Product Name: 24Dichloro-5methoxyacetanilide
• Synonyms: 24Dichloro-5methoxyacetanilide;4',6'-Dichloro-m-acetanisidide;N-(2,4-Dichloro-5-methoxyphenyl)acetamide
• CAS NO: 65182-98-1
• Molecular Formula: C₉H₉Cl₂NO₂
• Molecular Weight: 234.08
• Product Categories: Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds
• Mol File: 65182-98-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 158-159℃
• Boiling Point: 381.2 °C at 760 mmHg
• Flash Point: 184.3 °C
• Appearance: /
• Density: 1.373
• Vapor Pressure: 5.17E-06mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 24Dichloro-5methoxyacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 24Dichloro-5methoxyacetanilide(65182-98-1)
• EPA Substance Registry System: 24Dichloro-5methoxyacetanilide(65182-98-1)

Safety Data

• Hazardous Substances Data: 65182-98-1(Hazardous Substances Data)

Usage

Uses

N-(2,4-Dichloro-5-methoxyphenyl)acetamide is a reactant used in the chlorination of acetanilides with benzyltrimethylammonium tetrachloroiodate(B316185).

InChI:InChI=1/C9H9Cl2NO2/c1-5(13)12-8-4-9(14-2)7(11)3-6(8)10/h3-4H,1-2H3,(H,12,13)

Upstream product

• 67669-19-6 N-(2,4-dichloro-5-hydroxyphenyl)acetamide 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 591-27-5 m-Hydroxyaniline 
• 74-87-3 methylene chloride 
• 621-42-1 meta-hydroxyacetanilide 
• 588-16-9 m-methoxyacetanilide 

Downstream Products

• 98446-49-2 2,4-dichloro-5-methoxyaniline 
• 380843-75-4 bosutinib 
• 380844-49-5 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 
• 50375-04-7 1,3-dichloro-4,6-dimethoxybenzene 

Relevant articles and documents

Preparation method of mecitinib raw material (by machine translation)

The method comprises the following steps: preparing,methyl 3 -(-ethyl-)-amido phenol, dichloro - 5 5-methoxyaniline (by reaction with potassium chloride) sodium 2,4 - to generate (dichloro - 5 5-methan)-methaneth, 2,4 -amidobenzylether (in a chlorine substitution reaction). 2,4 - The method comprises the following steps: reacting m-methyl-methanethinonylphenol and hydrogen peroxide, to generate, dichloro - 5 5-methoxyaniline. The method comprises the following steps of reacting m-aminophenol as a raw material to synthesize methyl chloride 2,4 - potassium, and benzoyl (and reacting; with chloromethane in, a mixture) of, sodium, chloride and methyl chloride, and reacting with chloromethane in a reaction condition. (by machine translation)

New Synthetic Process for Bosutinib

A new and improved synthetic route to bosutinib is described on a hectogram scale. The key step is the intramolecular cyclization of a 3-(2-aminophenyl)-3-oxopropanenitrile with N,N-dimethylformamide dimethyl acetal to form the 3-cyano-4-hydroxyquinoline ring of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile. A practical synthetic method to 2,4-dichloro-5-methoxyaniline is also established. Bosutinib is obtained in 18.0% yield over nine steps from acetovanillone with 98.9% purity (HPLC).

Halogenation using quaternary ammonium polyhalides. XXIV.1()) Chlorination of acetanilides with benzyltrimethyl-ammonium tetrachloroiodate

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