65182-98-1

Usage

Uses

Used in Chemical Synthesis Industry:
24Dichloro-5methoxyacetanilide is used as a reactant for the chlorination of acetanilides with benzyltrimethylammonium tetrachloroiodate (B316185). This process is crucial in the synthesis of various organic compounds and intermediates, which can be further utilized in the development of pharmaceuticals, agrochemicals, and other specialty chemicals. The chlorination reaction allows for the introduction of chlorine atoms into the acetanilide structure, enabling the formation of new compounds with altered properties and potential applications.

InChI:InChI=1/C9H9Cl2NO2/c1-5(13)12-8-4-9(14-2)7(11)3-6(8)10/h3-4H,1-2H3,(H,12,13)

Upstream product

• 74-87-3 methylene chloride 
• 67669-19-6 N-(2,4-dichloro-5-hydroxyphenyl)acetamide 
• 591-27-5 m-Hydroxyaniline 
• 74-88-4 methyl iodide 
• 621-42-1 meta-hydroxyacetanilide 
• 588-16-9 m-methoxyacetanilide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 380843-75-4 bosutinib 
• 380844-49-5 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 
• 50375-04-7 1,3-dichloro-4,6-dimethoxybenzene 
• 98446-49-2 2,4-dichloro-5-methoxyaniline 

Relevant academic research and scientific papers

Preparation method of mecitinib raw material (by machine translation)

The method comprises the following steps: preparing,methyl 3 -(-ethyl-)-amido phenol, dichloro - 5 5-methoxyaniline (by reaction with potassium chloride) sodium 2,4 - to generate (dichloro - 5 5-methan)-methaneth, 2,4 -amidobenzylether (in a chlorine substitution reaction). 2,4 - The method comprises the following steps: reacting m-methyl-methanethinonylphenol and hydrogen peroxide, to generate, dichloro - 5 5-methoxyaniline. The method comprises the following steps of reacting m-aminophenol as a raw material to synthesize methyl chloride 2,4 - potassium, and benzoyl (and reacting; with chloromethane in, a mixture) of, sodium, chloride and methyl chloride, and reacting with chloromethane in a reaction condition. (by machine translation)

A PROCESS FOR THE PREPARATION OF BOSUTINIB

The present invention provides an improved process for the preparation of bosutinib and its intermediate 2-cyano-N-(2, 4-dichloro-5-methoxyphenyl)acetamide.

New Synthetic Process for Bosutinib

A new and improved synthetic route to bosutinib is described on a hectogram scale. The key step is the intramolecular cyclization of a 3-(2-aminophenyl)-3-oxopropanenitrile with N,N-dimethylformamide dimethyl acetal to form the 3-cyano-4-hydroxyquinoline ring of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile. A practical synthetic method to 2,4-dichloro-5-methoxyaniline is also established. Bosutinib is obtained in 18.0% yield over nine steps from acetovanillone with 98.9% purity (HPLC).

Herbicidal 1-aryl-4-substituted-1,4-dihydro-5H-tetrazol-5-ones and sulfur analogs thereof

Herbicidal aryltetrazolinones and thiones of the formula STR1 in which W is oxygen or sulfur; R is alkyl, fluoroalkyl, alkenyl, haloalkenyl, cyanoalkyl, alkylthioalkyl, haloalkoxyalkyl, trifluoromethylthio or alkoxyalkyl; one of X1 and X2 is fluorine, chlorine, or bromine and the other is fluorine, chlorine, bromine, alkyl, nitro or haloalkyl; and Z is a group selected from a variety of substituents including 2-propynyloxy as disclosed and exemplified.