65417-19-8Relevant academic research and scientific papers
RhIII-Catalyzed Straightforward Synthesis of Benzophenanthroline and Benzophenanthrolinone Derivatives using Anthranils
Biswas, Aniruddha,Sarkar, Souradip,Samanta, Rajarshi
, p. 3000 - 3004 (2019/02/13)
An efficient pot-economic and step-economic RhIII-catalyzed site-selective direct amination/annulation strategy was developed for the synthesis of benzophenanthroline derivatives using quinoline N-oxides and anthranils. The method was further extended to the synthesis of nitrogen-containing extended π-conjugated benzophenanthrolinone derivatives. Late-stage functionalizations of cinchonidine and cinchophen derivatives and synthesis of a bioactive quinolino-indole were achieved.
C-H Arylation of Heterocyclic N-Oxides Through in Situ Diazotisation of Anilines without Added Promoters: A Green and Selective Coupling Process
Colleville, Aymeric P.,Horan, Richard A. J.,Olazabal, Sandrine,Tomkinson, Nicholas C. O.
supporting information, p. 1283 - 1296 (2016/07/23)
A green and selective method for the generation of biaryl compounds through C-H arylation of heterocyclic N-oxides, in which the addition of ascorbic acid as a promoter is not required for either the generation of an aryldiazonium species or the subsequent arylation, is presented. Reaction conditions were optimized through multivariate data analysis, including orthogonal projections to latent structures (OPLS) and design of experiments (DoE) methodologies, resulting in further sustainability improvements, and were then applied to a range of substrates to establish the scope and limitations of the process. The reaction was studied using in situ infrared spectroscopy and a mechanism is presented that accounts for the available data from this and previous studies. The reaction was also performed on a multigram scale, with calorimetry studies to support further scale-up of this promoter-free transformation.
