65499-42-5 Usage
Type
Synthetic nucleoside analog of thymidine
Purpose
Antiretroviral medication for the treatment of HIV/AIDS
Mechanism of Action
Inhibits the reverse transcriptase enzyme, essential for HIV replication
Usage
Often used in combination with other antiretroviral drugs
Administration
Available in various formulations (capsules, oral solution) and taken orally
Side Effects
Potential side effects include peripheral neuropathy, pancreatitis, and lactic acidosis
Precaution
It is important to take stavudine as prescribed by a healthcare professional to optimize effectiveness and minimize adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 65499-42-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,4,9 and 9 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 65499-42:
(7*6)+(6*5)+(5*4)+(4*9)+(3*9)+(2*4)+(1*2)=165
165 % 10 = 5
So 65499-42-5 is a valid CAS Registry Number.
65499-42-5Relevant articles and documents
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Kobayashi et al.
, p. 536 (1977)
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Synthesis of nucleoside-based antiviral drugs in ionic liquids
Kumar, Vineet,Malhotra, Sanjay V.
supporting information; experimental part, p. 5640 - 5642 (2009/06/18)
Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.
Enzymatic regioselective acylation of the 3′-hydroxyl groups of 2′-deoxy-5-fluorouridine (FUdR) and 2′-Deoxy-5-trifiuoromethyluridine (CF3UdR)
Nozaki, Kenji,Uemura, Atuhiko,Yamashita, Jun-Ichi,Yasumoto, Mitsugi
, p. 7327 - 7328 (2007/10/02)
A lipase from Pseudomonas sp. (Amano PS) catalyzes regioselecfive acylation of the 3′-hydroxyl groups of FUdR and CF3UdR.
