67314-42-5Relevant articles and documents
4-Substituted-2-oxoazetidine compounds
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, (2008/06/13)
The present invention relates to novel 4-substituted-2-oxoazetidine compounds and to processes for preparing the same. These compounds are useful intermediates for preparing antibiotics having the basic skeleton of Thienamycin.
4-Substituted-2-oxoazetidine compounds and processes for the preparation thereof
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, (2008/06/13)
This invention relates to novel 4-substituted-2-oxoazetidine compounds and salts thereof, which are useful intermediates in the preparation of antibiotics having the fundamental skeleton of Thienamycin, which compounds are of the formula: STR1 in which R
Studies on the Syntheses of Heterocyclic Compounds. Part 877. An Alternative Synthesis of Protected (+/-)-Thienamycin and a Related Compound
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Yokohama, Shuichi,Ihara, Masataka
, p. 964 - 968 (2007/10/02)
An alternative total synthesis of protected (+/-)-thienamycin (2) and an analogue is described. (+/-)-4β-(2,2-Dimethoxyethyl)-3α-*)-1-(-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one (5), prepared from isoxazoline derivatives (4), was conve
Studies on the Syntheses of Heterocyclic Compounds. 800. A Formal Total Synthesis of (+/-)-Thienamycin and (+/-)-Decysteaminylthienamycin Derivative
Kametani, Tetsuji,Huang, Shyh-Pyng,Yokohama, Shuichi,Suzuki, Yukio,Ihara, Masataka
, p. 2060 - 2065 (2007/10/02)
The synthesis of a key intermediate for the preparation of (+/-)-thienamycin (1) and its derivatives has been developed.By 1,3-dipolar cycloaddition, the nitrile oxide derived from 3-nitropropanal dimethyl acetal (3) was added to methyl crotonate to give
AN ALTERNATIVE TOTAL SYNTHESIS OF (+/-)-THIENAMYCIN
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Ihara, Masataka
, p. 1305 - 1308 (2007/10/02)
(+/-)-4β-(2',2'-Dimethoxyethyl)-3α-(1'R*)-p-nitrobenzylocarbonyloxyethyl)-2-azetidinone (4) was converted into the thienamycin derivative (2) protected with p-nitrobenzyl group, utilizing the carbene insertion reaction and subsequent introduction of the c
Thienamycin Total Synthesis. 3. Total Synthesis of (+/-)-Thienamycin and (+/-)-8-Epithienamycin
Schmitt, Susan M.,Johnston, David B.R.,Christensen, B.G.
, p. 1142 - 1148 (2007/10/02)
The completion of the total synthesis of (+/-)-8-epithienamycin and (+/-)-thienamycin from azetidinones 3a and 3b using the methodology developed for the synthesis of model compound 4 (see part 2) is described.