6589-30-6

Upstream product

• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 100-42-5 styrene 
• 64-17-5 ethanol 

Downstream Products

• 6722-47-0 1-(2-ethoxy-2-phenyl-ethyl)-piperidine 
• 6230-62-2 (1-ethoxyvinyl)benzene 
• 76663-85-9 2-ethoxy-2-phenylethylamine 
• 54504-88-0 1-(β-ethoxy-phenethyl)-1-methyl-piperidinium; iodide 
• 121335-31-7 2-ethoxy-2-phenylethyl phenyl telluride 
• 4152-26-5 1-Aethoxy-1-phenyl-2-(diaethylamino)-aethan 
• 4714-21-0 4-methylstilbene 
• 4714-21-0 E-1-methyl-4-styryl-benzene 
• 91553-46-7 (β-ethoxy-phenethyl)-dimethyl-amine 
• 6722-51-6 2,2'-Phenylaethoxy-N-aethylpiperazin 
• 82486-29-1 2-methoxy-2-phenylethyl phenyl telluride 
• 6270-03-7 1,2-diacetoxy-1-phenyl-ethane 
• 32345-80-5 1,2-dimethoxyethylbenzene 
• 100-42-5 styrene 

Relevant academic research and scientific papers

Chemoenzymatic intermolecular haloether synthesis

A chemoenzymatic method for the synthesis of haloethers is presented. A combination of enzymatic hypohalite synthesis with spontaneous oxidation of alkenes and nucleophilic attack by various alcohols enabled the synthesis of a wide range of haloethers. The reaction system has been characterised and current imitations have been worked out. In the present, aqueous reaction system, hydroxyhalide formation represents the main undesired side reaction. Nevertheless, semi-preparative scale synthesis of a range of haloethers is demonstrated.

Alkene, Bromide, and ROH – How To Achieve Selectivity? Electrochemical Synthesis of Bromohydrins and Their Ethers

Bromohydrins and their ethers were electrochemically synthesized via hydroxy- and alkoxybromination of alkenes using potassium bromide and water or alcohols. High selectivity of bromohydrins formation was achieved only with the use of DMSO as the solvent and an acid as the additive. The proposed combination of starting reagents, additives, and solvents allowed to form bromohydrins or their ethers selectively despite the variety of side-products (epoxides, dibromides, diols). Bromohydrins were obtained in high yields, up to 96%, with a broad substrate scope in an undivided electrochemical cell equipped with glassy carbon and platinum electrodes at high current density. (Figure presented.).

Electrochemical bromofunctionalization of alkenes in a flow reactor

The bromination of organic molecules has been extensively studied to date, yet there is still a demand for safe and sustainable methodologies. Hazardous reagents, selectivity, low atom economy and waste production are the most persisting problems of brominating reagents. The electrochemical oxidation of bromide to bromine is a viable strategy to reduce waste by avoiding chemical oxidants. Furthermore, thein situgeneration of reactive intermediates minimizes the risk of hazardous reagents. In this work, we investigate the electrochemical generation of bromine from hydrobromic acid in a flow electrochemical reactor. Various alkenes could be converted to their corresponding dibromides, bromohydrines, bromohydrin ethers and cyclized products in good to excellent yields.

Mild and Efficient Vicinal Dibromination of Olefins Mediated by Aqueous Ammonium Fluoride

A mild and efficient vicinal dibromination of olefins has been developed by using saturated aqueous ammonium fluoride solution as the promoter. Inexpensive and commercially available N -bromosuccinimide (NBS) was used as the brominating reagent. The corresponding vicinal dibromoalkanes could be obtained in good to excellent yields.

Halofunctionalization of alkenes by vanadium chloroperoxidase from: Curvularia inaequalis

The vanadium-dependent chloroperoxidase from Curvularia inaequalis is a stable and efficient biocatalyst for the hydroxyhalogenation of a broad range of alkenes into halohydrins. Up to 1 200 000 TON with 69 s-1 TOF were observed for the biocatalyst. A bienzymatic cascade to yield epoxides as reaction products is presented.

BNBTS More than brominating agent: Green and one-pot route for the C-N bond formation in water from alkenes

In this paper, in addition to introducing efficient method for bromohydrin and bromoether preparation, simple, green and efficient method to C-N bond formation from alkene and N,N'-Dibromo-N,N'-1,2-ethanediyl- bis(ptoluenesulfonamide) [BNBTS] in water was investigated. The reaction between alkenes, β-cyclodexterin, and BNBTS took place in water afterward, by making media basic; it will give the corresponding valuable building blocks in good yields (45-79%).

Alkoxybromination of olefins using ammonium bromide and oxone

A mild, efficient, and highly regio- and stereoselective method for the methoxy and ethoxy bromination of olefins has been developed using NH 4Br as a bromine source and Oxone as an oxidant. Various kinds of olefins (aromatic, linear, and cyclic olefins) afforded the corresponding alkoxy brominated products in moderate to excellent yields. Taylor & Francis Group, LLC.

KETTENVERLAENGERUNG DURCH CARBONYLINSERTION BEI DER REAKTION VON (TETRACARBONYL)-(OLEFIN)EISEN(O)-KOMPLEXEN MIT OXIDATIONSMITTELN

On oxidation of (tetracarbonyl)(olefin)iron(O)-complexes in alcoholic solvents esters carrying a substituent in the 3-position are formed by a carbonylinsertion reaction.