31465-36-8

Usage

Uses

Used in Capillary Electrophoresis:
4-(4-Methoxyphenoxy)aniline is used as a potential indicator in capillary electrophoresis-based separations of zwitterionic compounds. Its unique chemical structure allows for effective separation and analysis of these compounds, making it a valuable tool in analytical chemistry.
Used in Synthesis of Dianthones:
4-(4-Methoxyphenoxy)aniline serves as a precursor in the synthesis of novel dianthrones, which are chemical compounds with potential antioxidant and anticancer activities. Its involvement in the synthesis process contributes to the development of these promising therapeutic agents.
Used in Development of Dye-Sensitized Solar Cells:
4-(4-Methoxyphenoxy)aniline is being studied for its potential as a photosensitizer in dye-sensitized solar cells. Its ability to absorb light and generate charge carriers makes it a candidate for improving the efficiency and performance of these solar energy conversion devices.

InChI:InChI=1/C13H13NO2/c1-15-11-6-8-13(9-7-11)16-12-4-2-10(14)3-5-12/h2-9H,14H2,1H3

Upstream product

• 6337-24-2 1-methoxy-4-(4-nitrophenoxy)benzene 
• 67-56-1 methanol 
• 139-59-3 4-phenoxyanilin 
• 857578-54-2 1,3-diiodo-2-methoxy-5-(4-nitro-phenoxy)-benzene 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 100-02-7 4-nitro-phenol 
• 100-00-5 4-chlorobenzonitrile 
• 150-76-5 4-methoxy-phenol 
• 350-46-9 4-Fluoronitrobenzene 
• 106-47-8 4-chloro-aniline 
• 106-40-1 4-bromo-aniline 
• 586-78-7 para-nitrophenyl bromide 
• 371-40-4 4-fluoroaniline 
• 123-30-8 4-amino-phenol 

Downstream Products

• 36161-00-9 2-chloro-N-(4-(4-methoxyphenoxy)phenyl)acetamide 
• 23745-17-7 Cyclopropanecarboxylic acid [4-(4-methoxy-phenoxy)-phenyl]-amide 
• 57181-50-7 2-Chloro-3-[4-(4-methoxy-phenoxy)-phenyl]-propionic acid ethyl ester 
• 69446-62-4 4-(4-methoxyphenoxy)-N,N-dimethylaniline 
• 43156-26-9 4-(p-methoxyphenoxy)-1,2-phenylendiamine 
• 860735-43-9 4-(4-methoxy-phenoxy)-2-nitro-aniline 
• 860577-95-3 acetic acid-[4-(4-methoxy-phenoxy)-2-nitro-anilide] 
• 23742-71-4 1-[4-(4-Methoxy-phenoxy)-phenyl]-3-(4-trifluoromethyl-phenyl)-urea 
• 51318-28-6 (Z)-4-[4-(4-Methoxy-phenoxy)-phenylamino]-3-methyl-but-2-enoic acid methyl ester 
• 873978-05-3 N-(4-(4-methoxyphenoxy)phenyl)acetamide 
• 26002-36-8 1-iodo-4-(4-methoxyphenoxy)benzene 

Relevant academic research and scientific papers

Oxalohydrazide Ligands for Copper-Catalyzed C?O Coupling Reactions with High Turnover Numbers

Here, we report a class of ligands based on oxalohydrazide cores and N-amino pyrrole and N-amino indole units that generates long-lived copper catalysts for couplings that form the C?O bonds in biaryl ethers. These Cu-catalyzed coupling of phenols with aryl bromides occurred with turnovers up to 8000, a value which is nearly two orders of magnitude higher than those of prior couplings to form biaryl ethers and nearly an order of magnitude higher than those of any prior copper-catalyzed coupling of aryl bromides and chlorides. This ligand also led to copper systems that catalyze the coupling of aryl chlorides with phenols and the coupling of aryl bromides and iodides with primary benzylic and aliphatic alcohols. A wide variety of functional groups including nitriles, halides, ethers, ketones, amines, esters, amides, vinylarenes, alcohols and boronic acid esters were tolerated, and reactions occurred with aryl bromides in pharmaceutically related structures.

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is

Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents

Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of Plasmodium falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.

Study on the structure-activity relations of brominated hydroxy diphenyl ethers derivatives with anilines

In order to study the influence of anilines on antibacterial activity, eight novel brominated hydroxy diphenyl ethers derivatives were designed and synthesized. The antibacterial activities of the new compounds were tested via agar-well diffusion method in vitro under different concentrations. The results showed the derivatives had antibacterial activities at the concentration 50 μg/mL against Staphylococcus aureus SC and Staphylococcus aureus ATCC26112.

INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS

This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.

Design, synthesis and antitumor activity of novel cis-furoquinoline derivatives

A series of novel cis-furoquinoline derivatives was synthesized and tested for their antitumor activities in vitro against HepG2 cells, Lu-04 cells and Leu02 cells to evaluate structure-activity relationships. Assay-based antiproliferative activity study revealed that several compounds had significant effects on cytotoxicity, among which compounds 2f, 2l, 2q were found to be the most active compounds. Above all, compounds 2f, 2l, 2q would be potential anticancer agents which deserved further research.

Efficient iron/copper-cocatalyzed o-arylation of phenols with bromoarenes

Low catalytic amount CuI and Fe(acac)3 were found to effectively promote the C-O cross-coupling reaction in the presence of K2CO 3 as the base. A serious of diaryl ethers with different substitutents can be synthesized in good to excellent yields. This efficient and economic method is attractive for applications on an industrial scale. Georg Thieme Verlag Stuttgart New York.

Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors

The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA4-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.

INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.