65964-62-7

Basic information

• Product Name: 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: BUTTPARK 11\05-12;2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE
• CAS NO: 65964-62-7
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 242.7
• Mol File: 65964-62-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE(65964-62-7)
• EPA Substance Registry System: 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE(65964-62-7)

Safety Data

• Hazardous Substances Data: 65964-62-7(Hazardous Substances Data)

Usage

General Description

2-(4-chloro-phenyl)-7-methyl-imidazo[1,2-a]pyridine is a chemical compound with the molecular formula C13H9ClN2. It is a heterocyclic organic compound that contains an imidazole ring fused to a pyridine ring. The presence of a 4-chloro-phenyl group and a methyl group in the molecule gives it unique chemical and biological properties. 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals for the treatment of various diseases and conditions. Its structure and properties make it a valuable resource for further research and development in the field of drug discovery.

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 99-91-2 para-chloroacetophenone 
• 184849-67-0 1-(4-chlorophenyl)ethanone O-acetyl oxime 
• 1956-39-4 4-chloroacetophenone oxime 
• 108-89-4 picoline 
• 23135-16-2 1,2-dibromo-1-(4-chlorophenyl)ethane 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 25357-43-1 1-(2-(4-chlorophenyl)-2-oxoethyl)-4-methylpyridinium bromide 

Downstream Products

• 65964-12-7 7-[(E)-2-(phenyl)vinyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridine 

Relevant articles and documents

Reduced Phenalenyl in Catalytic Dehalogenative Deuteration and Hydrodehalogenation of Aryl Halides

Dehalogenative deuteration reactions are generally performed through metal-mediated processes. This report demonstrates a mild protocol for hydrodehalogenation and dehalogenative deuteration of aryl/heteroaryl halides (39 examples) using a reduced odd alternant hydrocarbon phenalenyl under transition metal-free conditions and has been employed successfully for the incorporation of deuterium in various biologically active compounds. The combined approach of experimental and theoretical studies revealed a single electron transfer-based mechanism.

Novel one step synthesis of imidazo[1,2-a]pyridines and Zolimidine via iron/iodine-catalyzed Ortoleva-King type protocol

Imidazo[1,2-a]pyridines form versatile scaffolds in pharmaceutical industry arising from their diverse biological activities. The synthesis of these molecules thus has been of great interest and resulted in the development of a large number of new methodologies. Herein we describe the first iron-catalyzed Ortoleva-King type protocol towards the synthesis of these fused heterocyclic compounds. This methodology employs cheap and easily available FeCl3·6H2O and molecular iodine as the catalytic system. The procedure has been well explored by extending the substrate scope with a variety of aromatic ketones and 2-aminopyridines to furnish different imidazo[1,2-a]pyridine derivatives in moderate to good yields. A successful application of this protocol was also demonstrated by achieving direct one step synthesis of the gastro protective drug, Zolimidine.

Copper-catalyzed synthesis of imidazo[1,2-a]pyridines through tandem imine formation-oxidative cyclization under ambient air: One-step synthesis of zolimidine on a gram-scale

A new copper-catalyzed oxidative cyclization via C-H amination between 2-aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2-a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one-pot reaction protocol is applicable for the direct preparation of zolimidine (a marketed antiulcer drug) on a large scale. Copyright