66037-04-5

Basic information

• Product Name: Phenol, 5-bromo-2-methoxy-, acetate
• CAS NO: 66037-04-5
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Mol File: 66037-04-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Phenol, 5-bromo-2-methoxy-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 5-bromo-2-methoxy-, acetate(66037-04-5)
• EPA Substance Registry System: Phenol, 5-bromo-2-methoxy-, acetate(66037-04-5)

Safety Data

• Hazardous Substances Data: 66037-04-5(Hazardous Substances Data)

Usage

General Description

Phenol, 5-bromo-2-methoxy-, acetate is a chemical compound that combines phenol, a common organic compound, with bromine and methoxy groups. It is often used in chemical synthesis and as a precursor for the creation of other compounds. The acetate group attached to the phenol molecule provides stability and allows for easier manipulation of the compound in reactions. Phenol, 5-bromo-2-methoxy-, acetate may have various industrial applications due to its unique chemical structure, including in the production of pharmaceuticals, flavors, and fragrances.

Upstream product

• 60444-56-6 3-acetoxy-4-methoxybenzoic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 64-19-7 acetic acid 
• 881-57-2 isovanillin acetate 
• 621-59-0 isovanillin 
• 613-70-7 2-methoxyphenyl acetate 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 108-24-7 acetic anhydride 

Downstream Products

• 37942-01-1 5-bromo-2-methoxyphenol 
• 1333326-06-9 1-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclopentanol 
• 1357013-33-2 (R)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenylpent-4-ynoic acid 
• 608141-44-2 R-Apremilast 
• 608141-41-9 Apremilast 
• 635705-72-5 4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 915201-13-7 (3-ethoxy-4-methoxyphenyl)boronic acid 
• 52849-52-2 1-Bromo-3-ethoxy-4-methoxybenzene 
• 243990-54-7 (3-(benzyloxy)-4-methoxyphenyl)boronic acid 
• 344762-21-6 bis(3-hydroxy-4-methoxyphenyl)methane 

Relevant articles and documents

Direct Acetoxylation of Arenes

Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.

Methods for preparation of apremilast

The present invention discloses a method for preparation of Apremilast. β-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.

Synthesis and anti-inflammatory activity of isoquebecol

We report here the synthesis of isoquebecol, an unprecedented constitutional isomer of quebecol, a polyphenolic compound discovered in maple syrup. The methodology used to prepare isoquebecol involves, as key steps, the formation of a dibromoalkene from an α-ketoester precursor, followed by a double Suzuki-Miyaura reaction. The anti-inflammatory activity of isoquebecol was studied on macrophage cells by monitoring its ability to inhibit LPS-induced IL-6 secretion. Results show that this new compound has an improved bioactivity over that of its natural isomer. Precursors and derivatives of quebecol, isoquebecol and model analog 2,3,3-triphenylpropanol were also prepared and tested in this study. Comparison between the three series of compounds led to establishing new SARs concerning the aryl ring substitution pattern on the triarylpropanol scaffold and substructure functionalization.