421-07-8

Basic information

• Product Name: 1,1,1-TRIFLUOROPROPANE
• Synonyms: 1,1,1-TRIFLUOROPROPANE;1,1,1-trifluoro-propan;CH3CH2CF3;Propane, 1,1,1-trifluoro-;FC-263fb;1,1,1-Trifluoropropane97%
• CAS NO: 421-07-8
• Molecular Formula: C₃H₅F₃
• Molecular Weight: 98.07
• EINECS: 207-002-2
• Mol File: 421-07-8.mol
• Article Data: 34

Chemical Properties

• Melting Point: -148°C
• Boiling Point: -12°C
• Appearance: /
• Density: 1.0380
• Vapor Pressure: 2770mmHg at 25°C
• Refractive Index: 1.2600
• CAS DataBase Reference: 1,1,1-TRIFLUOROPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRIFLUOROPROPANE(421-07-8)
• EPA Substance Registry System: 1,1,1-TRIFLUOROPROPANE(421-07-8)

Safety Data

• Hazard Codes: F
• Statements: 12
• Safety Statements: 9-16-33
• RIDADR: 3161
• HazardClass: GAS, FLAMMABLE
• Hazardous Substances Data: 421-07-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 26, p. 1627, 1961 DOI: 10.1021/jo01064a601

InChI:InChI=1/C3H5F3/c1-2-3(4,5)6/h2H2,1H3

Upstream product

• 74-85-1 ethene 
• 2314-97-8 iodotrifluoromethane 
• 460-32-2 3-bromo-1,1,1-trifluoropropane 
• 661-54-1 3,3,3-trifluoroprop-1-yne 
• 677-21-4 1,1,1-trifluoropropylene 
• 432-04-2 tris(trifluoromethyl)phosphine 
• 201230-82-2 carbon monoxide 
• 383-63-1 ethyl trifluoroacetate, 
• 54128-17-5 trifluoromethanide 
• 407-25-0 trifluoroacetic anhydride 
• 2980-46-3 3,3,3-trifluoro-propyl 
• 421-02-3 1-chloro-1,1-difluoro-propane 
• 7783-56-4 antimony(III) fluoride 
• 7782-50-5 chlorine 

Downstream Products

• 460-35-5 3-chloro-1,1,1-trifluoropropane 
• 421-46-5 1,1,1-trifluoro-2-bromo-propane 
• 460-32-2 3-bromo-1,1,1-trifluoropropane 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 461-35-8 1,1,1-trifluoro-3-nitropropane 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 819-07-8 1,1,1-trifluoro-2-nitroethane 
• 1652-89-7 1,1,1,2,2-pentachloro-3,3,3-trifluoropropane 
• 460-69-5 1,1-dichloro-3,3,3-trifluoropropane 
• 7125-84-0 1,1,1-trichloro-3,3,3-trifluoropropane 
• 421-47-6 1,1,1-trifluoroisopropyl chloride 
• 7125-94-2 3,3-dibromo-1,1,1-trifluoro-propane 
• 74-84-0 ethane 
• 74-85-1 ethene 

Relevant articles and documents

Reactivity of 3,3,3-Trifluoropropyne at Rhodium Complexes: Development of Hydroboration Reactions

The rhodium compounds [Rh(C≡CCF3)(PEt3)3] (2), fac-[RhH(C≡CCF3)2(PEt3)3] (3), and fac-[Rh{(E)-CH=CHCF3}(C≡CCF3)2(PEt3)3] (4) were synthesized by reactions of the rhodium(I) complexes [Rh(H)(PEt3)3] (1) and [Rh(Bpin)(PEt3)3] (5, HBpin=pinacolborane) with the alkyne 3,3,3-trifluoropropyne. Reactivity studies of [Rh(C≡CCF3)(PEt3)3] (2) were performed with CO and 13CO to form [Rh(C≡CCF3)(CO)(PEt3)3] (7) and subsequently trans-[Rh(C≡CCF3)(CO)(PEt3)2] (8) as well as the labeled derivatives. Using 1–4 as catalysts, hydroboration reactions selectively afforded borylated building blocks.

Versatile Reaction Pathways of 1,1,3,3,3-Pentafluoropropene at Rh(I) Complexes [Rh(E)(PEt3)3] (E=H, GePh3, Si(OEt)3, F, Cl): C-F versus C-H Bond Activation Steps

The reaction of the rhodium(I) complexes [Rh(E)(PEt3)3] (E=GePh3 (1), H (6), F (7)) with 1,1,3,3,3-pentafluoropropene afforded the defluorinative germylation products Z/E-2-(triphenylgermyl)-1,3,3,3-tetrafluoropropene and

C?H and C?F Bond Activation Reactions of Fluorinated Propenes at Rhodium: Distinctive Reactivity of the Refrigerant HFO-1234yf

The reaction of [Rh(H)(PEt3)3] (1) with the refrigerant HFO-1234yf (2,3,3,3-tetrafluoropropene) affords an efficient route to obtain [Rh(F)(PEt3)3] (3) by C?F bond activation. Catalytic hydrodefluorinations were achieved in the presence of the silane HSiPh3. In the presence of a fluorosilane, 3 provides a C?H bond activation followed by a 1,2-fluorine shift to produce [Rh{(E)-C(CF3)=CHF}(PEt3)3] (4). Similar rearrangements of HFO-1234yf were observed at [Rh(E)(PEt3)3] [E=Bpin (6), C7D7 (8), Me (9)]. The ability to favor C?H bond activation using 3 and fluorosilane is also demonstrated with 3,3,3-trifluoropropene. Studies are supported by DFT calculations.