6624-02-8

Basic information

• Product Name: 3-hydroxy-1,3,3-triphenyl-propan-1-one
• Synonyms: 3-hydroxy-1,3,3-triphenyl-propan-1-one
• CAS NO: 6624-02-8
• Molecular Formula: C₂₁H₁₈O₂
• Molecular Weight: 0
• Mol File: 6624-02-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 502.9°C at 760 mmHg
• Flash Point: 213.1°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 6.17E-11mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 3-hydroxy-1,3,3-triphenyl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-1,3,3-triphenyl-propan-1-one(6624-02-8)
• EPA Substance Registry System: 3-hydroxy-1,3,3-triphenyl-propan-1-one(6624-02-8)

Safety Data

• Hazardous Substances Data: 6624-02-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H18O2/c22-20(17-10-4-1-5-11-17)16-21(23,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,23H,16H2

Upstream product

• 60-29-7 diethyl ether 
• 62961-62-0 (Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one 
• 591-51-5 phenyllithium 
• 120-46-7 1,3-diphenylpropanedione 
• 105-53-3 diethyl malonate 
• 100-58-3 phenylmagnesium bromide 
• 1522-13-0 1,1,3-triphenylprop-2-yn-1-ol 
• 73510-68-6 (2-Phenyl-1,3-dithian-2-yl)essigsaeure-ethylester 
• 108-86-1 bromobenzene 
• 78485-09-3 3,3,5-Triphenyl-1,2-dioxacyclopentane 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 76283-96-0 1,1-Diphenyl-2-(2-phenyl-[1,3]dithian-2-yl)-ethanol 
• 606-86-0 1,3,3-triphenylpropan-1-one 
• 119-61-9 benzophenone 

Downstream Products

• 849-01-4 1,3,3-triphenylprop-2-en-1-one 
• 119-61-9 benzophenone 
• 98-86-2 acetophenone 
• 612-96-4 2-Phenylquinoline 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 2515-48-2 1,3,5,5-tetraphenyl-4,5-dihydro-1H-pyrazole 
• 408521-43-7 2-bromo-1,3,3-triphenyl-propenone 

Relevant articles and documents

Isopropylmagnesium chloride-promoted unilateral addition of Grignard reagents to β-diketones: One-pot syntheses of β-tertiary hydroxyl ketones or 3-substituted cyclic-2-enones

The regioselective unilateral additions of Grignard reagents to acyclic or cyclic β-diketones were effectively promoted by sub-stoichiometric amounts of i-PrMgCl to afford β-tertiary hydroxyl ketones or 3-substituted cyclic-2-enones, respectively. Also, the addition of Grignard reagents to acyclic β-diketones followed by a reaction with cyclic β-diketones in a one-pot process was put forward. The reaction mechanism was discussed in detail to explain the high regioselectivity via chemical experiments, hydrogen-deuterium exchange and mass spectrometry.

Novel photo-rearrangements of 3,3,5-triaryl-1,2-dioxolanes: Evidence for 1,5-dioxyl diradical intermediates

3-(p-Methoxyphenyl)-substituted 1,2-dioxolanes undergo novel photo-rearrangements to afford 1,3-diaryl-3-(p-methoxyphenoxy)propan-1-ones along with 1,3,3-triaryl-3-hydroxypropan-1-ones via 1,5-dioxyl diradical intermediates.

Oxidation of Alkenes and Sulphides with a Series of Hydroperoxides having Electron-withdrawing Substituents at the α-Position

The oxidations of alkenes and sulphides with a series of hydroperoxides, α-hydroperoxy-α-methoxyacetophenone (1), α-hydroperoxy-α,α-diphenylacetophenone (2), methyl α-hydroperoxy-α,α-diphenylacetate (3), and α-hydroperoxy-α,α-diphenylacetonitrile (4), were undertaken in a systematic fashion.The data revealed the following. (a) The reactions of electron-rich alkenes (11a and b) with hydroperoxides (1)-(4) are most likely to proceed by a mechanism similar to that with peracids, as do the oxidations of sulphides (5a-e). (b) For the reaction of less reactive alkenes (11f-k) with hydroperoxide (1) in the presence of oxygen, epoxidation by benzoylperoxyl radical contributes to a significantextent.The reaction with hydroperoxide (2) at 60 deg C also seems to proceed by a mechanism involving benzoylperoxyl radical, whereas a molecular epoxidation mechanism is important for the reaction at 30 deg C.Perhaps in accord with this, the reaction of 1,1-disubstituted ethylenes (11c-e) with hydroperoxides (1) and (2) results in the formation of considerable amounts of benzoylated products (13) and (14). (c) For the epoxidation with hydroperoxides (3) and (4), however, a molecular epoxidation process seems to predominate.The exception is the reaction of hydroperoxide (3) with (Z)-2-phenylbut-2-ene and (Z)-stilbene, having very poor reactivity, in which a peroxyl radical, produced by hydrogen abstraction from the hydroperoxide (3), plays an important role in the epoxidation.