66353-47-7

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichlorobutyrophenone is utilized as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of active ingredients in medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DCBP serves as an intermediate in the production of various agrochemicals, playing a crucial role in the formulation of substances that protect crops and enhance agricultural productivity.
Used in Fragrance and Flavor Industry:
2,4-Dichlorobutyrophenone is employed in the creation of fragrances and flavors, capitalizing on its chemical properties to develop a range of scents and tastes for different consumer products.

InChI:InChI=1/C10H10Cl2O/c1-2-3-10(13)8-5-4-7(11)6-9(8)12/h4-6H,2-3H2,1H3

Upstream product

• 927-77-5 n-propylmagnesium bromide 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 53066-18-5 1-(2,4-dichlorophenyl)butan-1-ol 
• 2234-82-4 1-propylmagnesium chloride 
• 7681-65-4 copper(I) iodide 
• 89-75-8 2,4-dichlorobenzoyl chloride 

Downstream Products

• 172988-67-9 ethyl 5-(2,4-dichlorophenyl)-4-ethyl-2-methyl-3,5-dioxopentanoate 
• 78967-81-4 C₁₀H₉BrCl₂O 
• 93363-54-3 1-(2,4-Dichloro-phenyl)-2-hydroxy-2-[1,2,4]triazol-1-ylmethyl-butan-1-one 

Relevant academic research and scientific papers

Inhibitors of glycogen synthase kinase 3

New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

Inhibitors of glycogen synthase kinase 3

Novel pyridine and pyrimidine derivatives which selectively inhibit glycogen synthase kinase 3 are provided and methods of preparing these compounds are provided. These compounds are useful in treating certain conditions which may be mediated by glycogen synthase kinase 3.

Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole

Some new oxime ethers of types 7 and 8, in which the methyleneaminoxy group, C=N-O, of oxiconazole 6 is in an inverted atomic sequence, were synthesized and tested for their antifungal activities. Among them, the type 7 compounds, such as the N-ethoxy-morpholino-substituted derivatives 71-o (Table 1), showed good antifungal properties against the Candida strains tested, with minimum inhibitory concentration (MIC) values similar to those of the reference drug 6. A remarkable result was obtained with these types of azoles, which had shown a cidal character against Candida albicans, while the reference drug oxiconazole was only fungistatic in the same tests. This fact may be seen from a comparison of the MIC values with those of the minimum fungicidal concentration (MFC) values for most of the type 7 compounds assayed that have shown differences between the MIC and the MFC, which are lower than three double diluitions. A simple molecular modeling of the P450 14-α-sterol demethylase from C. albicans (Candida P450DM) was built in order to understand how the structural differences between type 7 compounds and oxiconazole 6 can induce different antifungal profiles. The results of this work seem to confirm that it is possible to reverse the atomic sequence of the methyleneaminoxy group, C=N-O, of 6, obtaining new imidazoles possessing good antifungal properties.

An Approach to Substituted 4-Hydroxypyran-2-ones

We examined a method for the preparation of 4-hydroxypyran-2-ones in two steps from aryl ketones and ethyl malonyl chloride (or ethyl 2-methylmalonyl chloride).These 4-hydroxypyran-2-ones are useful precursors as they may be transformed in two steps to the 2-methoxypyran-4-ones, which is found in phenoxan - a naturally occurring compound discovered to have anti-HIV activity.