66399-70-0

Basic information

• Product Name: L-Leucine, N-(phenylmethyl)-, methyl ester
• CAS NO: 66399-70-0
• Molecular Formula: C14H21NO2
• Molecular Weight: 235.326
• Mol File: 66399-70-0.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-(phenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-(phenylmethyl)-, methyl ester(66399-70-0)
• EPA Substance Registry System: L-Leucine, N-(phenylmethyl)-, methyl ester(66399-70-0)

Safety Data

• Hazardous Substances Data: 66399-70-0(Hazardous Substances Data)

Upstream product

• 1010385-26-8 N-benzyl-N-methyl-L-leucine methyl ester 
• 2666-93-5 (S)-Leu-OMe 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 3005-60-5 N-benzoyl-L-leucine methyl ester 
• 61-90-5 L-leucine 
• 100-39-0 benzyl bromide 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 247246-78-2 (S)-4-Methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-pentanoic acid methyl ester 
• 67-56-1 methanol 
• 35661-60-0 Fmoc-Leu-OH 
• 100-51-6 benzyl alcohol 
• 176239-73-9 (S)-N-(4-methyl-3-pentenyl)leucine methyl ester 
• 75691-28-0 methyl (S)-2-(benzylideneamino)-4-methylpentanoate 

Downstream Products

• 387859-83-8 5-benzyl-4-isobutyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-3-one 
• 10249-88-4 (S)-4-methyl-[(phenylmethyl)amino]pentan-1-ol 
• 1372807-63-0 C₂₈H₃₉N₃O₆ 
• 1372807-96-9 (S)-2-(4-methoxybenzyl)-4-benzyl-5-isobutyl-[1,2,4]-triazine-3,6-dione 
• 1372807-95-8 (S)-2,4-dibenzyl-5-isobutyl-[1,2,4]triazine-3,6-dione 
• 1372807-61-8 C₂₇H₃₇N₃O₅ 
• 1372807-62-9 C₂₆H₃₅N₃O₅ 
• 1010385-26-8 N-benzyl-N-methyl-L-leucine methyl ester 
• 1403983-88-9 2-[benzyl(methyl)amino]-4-methyl-1,1-diphenylpentan-1-ol 
• 1161828-77-8 N-benzyl-N-methyl-L-leucinol 
• 40297-72-1 2-(benzylamino)-4-methylpentanoic acid 

Relevant articles and documents

Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor

Despite the fact that continuous flow processing exhibits well-established technical advances, aqueous micellar chemistry, a field that has proven extremely useful in shifting organic synthesis to sustainable water-based media, has mostly been explored under conventional batch-based conditions. This is particularly because of the fact that the reliable handling of slurries and suspensions in flow has been considered as a significant technical challenge. Herein, we demonstrate that the strategic application of an oscillatory plug flow reactor enables heterogeneous catalytic reductive aminations in aqueous micellar media enhancing mass transport and facilitating process simplicity, stability and scalability. The micellar flow process enabled a broad range of substrates, including amino acid derivatives, to be successfully transformed under reasonably mild conditions utilizing only very low amounts of Pd/C as a readily available heterogeneous catalyst. The preparative capabilities of the process along with the recyclability of the heterogenous catalyst and the aqueous reaction media were also demonstrated. This journal is

ANTIVIRAL COMPOUNDS

The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.

Substrate-Controlled Diastereoselectivity Reversal in NHC-Catalyzed Cross-Benzoin Reactions Using N-Boc-N-Bn-Protected α-Amino Aldehydes

The effectiveness of utilizing N-Bn-N-Boc-α-amino aldehydes in cross-benzoin reactions with heteroaromatic aldehydes is demonstrated. The reaction is both chemoselective and syn-selective, making it complementary to the anti-selective cross-benzoin reaction of NHBoc-α-amino aldehydes. Good diastereoselectivity is obtained for a variety of amino aldehydes, including nonhindered ones. A Felkin-Anh model can be used to rationalize the observed diastereoselectivity.