66778-36-7

Basic information

• Product Name: BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
• Synonyms: BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-;(±)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide;Enkade;Enkaid;MJ-9067;4-Methoxy-2'-[2-(1-methyl-3-piperidyl)ethyl]benzanilide;M-9067-1;MJ-9067[AS BASE]
• CAS NO: 66778-36-7
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.47
• Mol File: 66778-36-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-(66778-36-7)
• EPA Substance Registry System: BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-(66778-36-7)

Safety Data

• Hazardous Substances Data: 66778-36-7(Hazardous Substances Data)

Usage

Definition

ChEBI: 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life- hreatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.

Upstream product

• 109-06-8 α-picoline 
• 7730-87-2 1-methylpiperidine-2-carboxylic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 37611-80-6 2-(ortho-aminophenethyl)-1-methylpiperidine 
• 153707-63-2 4-methoxy-N-<2-<1-hydroxy-2-(2-pyridinyl)ethyl>phenyl>benzamide 
• 87165-92-2 4-methoxy-N-<2-(2-pyridinylacetyl)phenyl>benzamide 
• 37619-28-6 methyl 2-[(4-methoxybenzoyl)amino]benzoate 
• 153707-65-4 N-{2-[1-Hydroxy-2-(1-methyl-1,2,5,6-tetrahydro-pyridin-2-yl)-ethyl]-phenyl}-4-methoxy-benzamide 
• 50-00-0 formaldehyd 
• 87085-10-7 N-Desmethylencainide 

Downstream Products

• 58754-42-0 2-[2-[(p-methoxybenzyl)amino]phenethyl]-1-methylpiperidine 

Relevant articles and documents

Decarboxylative Anti-Michael Addition to Olefins Mediated by Photoredox Catalysis

Decarboxylative coupling of carboxylic acids with activated olefins has been accomplished using visible light photoredox catalysis. The strategic placement of a radical-stabilizing aromatic group at the β-position of the olefin component biases the regios

Substituted piperidines

The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.