66778-36-7

Usage

Uses

Used in Pharmaceutical Industry:
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]is used as an antiarrhythmic agent for the treatment of severe or life-threatening ventricular arrhythmias. Its hydrochloride salt was previously utilized in the pharmaceutical industry for this purpose.
However, it was later associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack, leading to its withdrawal from the market. Despite this setback, the compound's properties and potential applications in the field of cardiology may still be of interest for further research and development.

Upstream product

• 50-00-0 formaldehyd 
• 87085-10-7 N-Desmethylencainide 
• 153707-65-4 N-{2-[1-Hydroxy-2-(1-methyl-1,2,5,6-tetrahydro-pyridin-2-yl)-ethyl]-phenyl}-4-methoxy-benzamide 
• 109-06-8 α-picoline 
• 37619-28-6 methyl 2-[(4-methoxybenzoyl)amino]benzoate 
• 87165-92-2 4-methoxy-N-<2-(2-pyridinylacetyl)phenyl>benzamide 
• 153707-63-2 4-methoxy-N-<2-<1-hydroxy-2-(2-pyridinyl)ethyl>phenyl>benzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 37611-80-6 2-(ortho-aminophenethyl)-1-methylpiperidine 
• 7730-87-2 1-methylpiperidine-2-carboxylic acid 

Downstream Products

• 58754-42-0 2-[2-[(p-methoxybenzyl)amino]phenethyl]-1-methylpiperidine 

Relevant academic research and scientific papers

Decarboxylative Anti-Michael Addition to Olefins Mediated by Photoredox Catalysis

Decarboxylative coupling of carboxylic acids with activated olefins has been accomplished using visible light photoredox catalysis. The strategic placement of a radical-stabilizing aromatic group at the β-position of the olefin component biases the regios

Substituted piperidines

The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.