66875-48-7

Upstream product

• 67570-38-1 α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 328-73-4 3,5-bis(trifluoromethyl)iodobenzene 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 

Downstream Products

• 34815-78-6 3-<3,5-bis(trifluoromethyl)phenyl>butan-2-ol 
• 155619-07-1 3-<3,5-bis(trifluoromethyl)phenyl>(1-¹³C)butan-2-one 
• 1402166-97-5 1-(1-nitropropan-2-yl)-3,5-bis(trifluoromethyl)benzene 
• 1402166-84-0 (E)-1-(1-nitroprop-1-en-2-yl)-3,5-bis(trifluoromethyl)benzene 
• 155619-04-8 2-<3,5-bis(trifluoromethyl)phenyl>propan-1-ol 
• 75724-06-0 3,5-bis(trifluoromethyl)cumyl chloride 
• 65638-55-3 3,5-Bis(trifluormethyl)cumen 

Relevant academic research and scientific papers

Electron-deficient olefin ligands enable generation of quaternary carbons by Ni-catalyzed cross-coupling

A Ni-catalyzed Negishi cross-coupling with 1,1-disubstituted styrenyl aziridines has been developed. This method delivers valuable β-substituted phenethylamines via a challenging reductive elimination that affords a quaternary carbon. A novel electron-deficient olefin ligand, Fro-DO, proved crucial for achieving high rates and chemoselectivity for C-C bond formation over β-H elimination. This ligand is easy to access, is stable, and presents a modular framework for reaction discovery and optimization. We expect that these attributes, combined with the fact that the ligands impart distinct electronic properties to a metal, will support the invention of new transformations not previously possible using established ligands.

Highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes

Building the building blocks: A highly enantioselective hydrogenation of ?-aryl-?-alkyl disubstituted nitroalkenes 1 has been developed. This method results in enantiomerically pure nitroalkanes 2, which are versatile precursors for chemical synthesis.

Acetolysis of 2-Aryl-1-methylpropyl Systems: Mechanism of the Formation of the Retained Product without Neighbouring Group Participation

threo-2--1-(13C)methylpropyl p-bromobenzenesulphonate (threo-(13C)1-OBs) has been solvolyzed in acetic acid to give rise to the retained threo-1-OAc which contains a small amount of threo-(13C)1-OAc accompanying no 13C-scrambling.At 75percent conversion, the isomerized erythro-1-OBs has been obtained along with the unchanged threo-1-OBs.Also, the erythro-1-OTs has been found at 50percent conversion in the presence of NaOTs.These stereochemical results indicate strongly that the acetate with the retained configuration accompanying no 13C-scrambling is formed via isomerization of the substrate by inversive anion exchange and a successive ks pathway with configurational inversion.Such a retained product was not detected in the acetolysis of threo-1-methyl-2-phenylpropyltoluene-p-sulphonate with no electron withdrawing substituent.

Solvolysis of 2-aryl-exo-5,6-trimethylene-2-norbornyl p-nitrobenzoates as a reference of 2-aryl-2-norbornyl p-nitrobenzoates solvolysis. Further evidence for the unimportance of σ-participation in the solvolysis of 2-aryl-2-norbornyl derivatives

The rates of solvolysis of 2 - aryl - exo - 5,6 - trimethylene - exo - and endo - 2 - norbornyl p-nitrobenzoates (7 and 8, respectively) with representative substituents [p-CH3O, p-CH3, H, m-CF3, p-CF3, and 3,5-