67570-38-1

Usage

Uses

Used in Organic Synthesis:
2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol is utilized as a reagent in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a wide range of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol serves as a building block for the synthesis of pharmaceutical compounds, leveraging its unique structural features to enhance the properties of resulting drugs.
Used in Agrochemical Production:
2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol is employed in the production of agrochemicals, where its chemical properties can be harnessed to develop effective products for agricultural applications.
Used in Dye Manufacturing:
2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol is also used in the manufacturing of dyes, capitalizing on its chemical structure to produce a variety of colorants for different industries.
Used in Polymer Production:
2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol contributes to the production of polymers, where its properties can influence the characteristics of the final polymeric materials.
It is crucial to handle 2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol with care due to the potential hazards associated with the trifluoromethyl groups, ensuring safe and proper usage in all applications.

InChI:InChI=1/C11H10F6O/c1-9(2,18)6-3-7(10(12,13)14)5-8(4-6)11(15,16)17/h3-5,18H,1-2H3

Upstream product

• 328-73-4 3,5-bis(trifluoromethyl)iodobenzene 
• 67-64-1 acetone 
• 112981-69-8 3,5-bis(trifluoromethyl)phenylmagnesium bromide 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 

Downstream Products

• 66875-48-7 1-(prop-1-en-2-yl)-3,5-bis(trifluoromethyl)benzene 
• 67595-63-5 1-<3,5-bis(trifluoromethyl)phenyl>-1-methylethylium 
• 873458-48-1 N-{1-(3,5-bistrifluoro-methylphenyl)-1-methyl-ethyl}-N-formamide 
• 155619-06-0 3-<3,5-bis(trifluoromethyl)phenyl>(1-¹³C)butan-2-ol 
• 155619-07-1 3-<3,5-bis(trifluoromethyl)phenyl>(1-¹³C)butan-2-one 
• 155619-05-9 2-<3,5-bis(trifluoromethyl)phenyl>propanal 
• 155619-04-8 2-<3,5-bis(trifluoromethyl)phenyl>propan-1-ol 
• 34815-78-6 3-<3,5-bis(trifluoromethyl)phenyl>butan-2-ol 
• 289686-69-7 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride 
• 290297-26-6 netupitant 
• 290296-68-3 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide 
• 289686-70-0 α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 

Relevant academic research and scientific papers

Synthesis method of netupitant intermediate (2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propionic acid)

The invention discloses a synthesis method of a netupitant intermediate (2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propionic acid). The method includes the following steps of adding a compound III and trimethylcyanosilane to an organic solvent, cooling the organic solvent to 0 DEG C, dropwise adding an acid catalyst, heating reaction liquid to the room temperature after dropwise adding is completed, conducting quenching, extracting, organic phase drying, filtering, filtrate concentrating, recrystallizing, filtering and drying on reaction liquid after reaction ends to obtain a compound II, adding water to the compound II, dropwise adding concentrated sulfuric acid for reflux reaction, and conducting quenching, extracting, organic phase drying, filtering, concentrating, filtering and drying on the reaction liquid after reaction ends. The method has the advantages that the adopted synthesis method is simple in step, a highly-toxic product (methyl iodide) or a metal palladium catalyst is avoided, the reaction route is short, the raw materials are low in price and easy to obtain, the reaction conditions are mild, the production process is simple in operation, the product yield is high, and thus the method is suitable for large-scale production.

PIPERIDINE COMPOUND AND METHOD FOR PRODUCING SAME

The present invention relates to a novel piperidine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally

Efficient synthesis of novel NK1 receptor antagonists: Selective 1,4-addition of Grignard reagents to 6-chloronicotinic acid derivatives

A new efficient synthesis of two novel classes of NK1 receptor antagonists, among them befetupitant and netupitant, starting from 6-chloronicotinic acid is described. The introduction of the o-tolyl substituent at C(4) of the pyridine ring was achieved by a one-pot selective 1,4-Grignard addition/oxidation sequence to 6-chloronicotinic acid or a derivative of it. The scope of this addition/oxidation sequence was examined. It was also shown that the carboxylic function can be converted to a methyl amino group by a Hofmann rearrangement followed by reduction. Furthermore, a new high-yielding synthesis of 2-(3,5-bistrifluoromethylphenyl)-2-methyl propionic acid based on the carbonylation of the tertiary alcohol obtained by Grignard addition of 3,5-bis(trifluoromethyl)bromobenzene to acetone was established.

Process for preparation of 2-phenyl acetic acid derivatives

The present invention is a process for the preparation of a compound of formula The compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds.

Acetolysis of 2-Aryl-1-methylpropyl Systems: Mechanism of the Formation of the Retained Product without Neighbouring Group Participation

threo-2--1-(13C)methylpropyl p-bromobenzenesulphonate (threo-(13C)1-OBs) has been solvolyzed in acetic acid to give rise to the retained threo-1-OAc which contains a small amount of threo-(13C)1-OAc accompanying no 13C-scrambling.At 75percent conversion, the isomerized erythro-1-OBs has been obtained along with the unchanged threo-1-OBs.Also, the erythro-1-OTs has been found at 50percent conversion in the presence of NaOTs.These stereochemical results indicate strongly that the acetate with the retained configuration accompanying no 13C-scrambling is formed via isomerization of the substrate by inversive anion exchange and a successive ks pathway with configurational inversion.Such a retained product was not detected in the acetolysis of threo-1-methyl-2-phenylpropyltoluene-p-sulphonate with no electron withdrawing substituent.

Solvolysis of 2-aryl-exo-5,6-trimethylene-2-norbornyl p-nitrobenzoates as a reference of 2-aryl-2-norbornyl p-nitrobenzoates solvolysis. Further evidence for the unimportance of σ-participation in the solvolysis of 2-aryl-2-norbornyl derivatives

The rates of solvolysis of 2 - aryl - exo - 5,6 - trimethylene - exo - and endo - 2 - norbornyl p-nitrobenzoates (7 and 8, respectively) with representative substituents [p-CH3O, p-CH3, H, m-CF3, p-CF3, and 3,5-