671815-99-9

Usage

Uses

Used in Pharmaceutical Industry:
(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid is used as an intermediate for the synthesis of Rho kinase inhibitors. Rho kinase inhibitors are essential in treating conditions such as hypertension, stroke, and other cardiovascular diseases by regulating the activity of Rho kinase, a protein involved in smooth muscle contraction and cell motility.
(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid is also used as an intermediate for the synthesis of neurite outgrowth promoters. These promoters play a crucial role in the development and repair of the nervous system, as they stimulate the growth and elongation of neurites, which are essential for the proper functioning of neurons.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 149004-75-1 trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 36283-44-0 N-acetyl-1-phenylethylamine 
• 88146-37-6 (R)-N-(1-(4-acetylphenyl)ethyl)acetamide 
• 859163-61-4 (R)-4-(1-acetamidoethyl)benzoic acid 
• 1318865-17-6 trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid methyl ester 
• 15177-67-0 trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 32529-80-9 trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane 
• 183996-94-3 trans-4-acetylcyclohexanecarboxylic acid methyl ester 

Downstream Products

• 671816-04-9 trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate 
• 129830-38-2 (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide dihydrochloride 
• 1318865-29-0 C₁₉H₂₈FN₃O₃ 
• 1318865-32-5 C₁₉H₂₈FN₃O₃ 

Relevant academic research and scientific papers

SMALL MOLECULE INHIBITORS OF ULK1

The present technology is directed to compounds, compositions, and methods related to inhibition of ULK1 and treatment of cancers therefrom.

A Rho kinase inhibitor Y27632 method for the preparation of compounds

The invention discloses a preparation method of a Rho kinase inhibitor Y27632 compound. Chirality of amine is constructed through a CBS reduction method high in selectivity to obtain amine with high optical purity, thus effectively and rapidly realizing s

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro deriv

1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES

Allylic compounds represented by the formula (I) are provided, wherein each of R1 to R8, m, n, A and X are as defined in the Specification. These compounds can inhibit Rho kinase, and can find utility in repair of damaged nerves in the central and peripheral nervous system by inducing axon growth and regeneration, and in the treatment by inhibition of Rho kinase in disease states in which Rho kinase is implicated. The compounds are relatively cell permeable and pharmaceutical compositions thereof can promote neurite growth and are also useful for the prevention of cell proliferation in malignant deseases.