88146-37-6

Basic information

• Product Name: N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide
• Synonyms: N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide
• CAS NO: 88146-37-6
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Product Categories: Aromatics;Chiral Reagents;Miscellaneous Reagents
• Mol File: 88146-37-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane, Methanol
• CAS DataBase Reference: N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide(88146-37-6)
• EPA Substance Registry System: N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide(88146-37-6)

Safety Data

• Hazardous Substances Data: 88146-37-6(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

N-[(1R)-1-(4-Acetylphenyl)ethyl]acetamide is useful for the preparation of piperazine derivatives as TNF production inhibitors and IL-10 production promoters.

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 36283-44-0 N-acetyl-1-phenylethylamine 
• 75-36-5 acetyl chloride 

Downstream Products

• 671816-04-9 trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate 
• 129830-38-2 (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide dihydrochloride 
• 1320213-55-5 trans-(R)-4-(1-acetamidoethyl)cyclohexanecarboxylic acid 
• 1318865-32-5 C₁₉H₂₈FN₃O₃ 
• 1318865-29-0 C₁₉H₂₈FN₃O₃ 
• 671815-99-9 (1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid 
• 1318865-17-6 trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid methyl ester 
• 1318865-18-7 trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid hydrochloride 
• 173898-18-5 (R)-N-(4-methoxycarbonylphenylethyl)acetamide 
• 223514-69-0 (R)-N-(1-(4-hydroxymethylphenyl)ethyl)acetamide 
• 223514-71-4 (R)-N-(1-(4-chloromethylphenyl)ethyl)acetamide 
• 859163-61-4 (R)-4-(1-acetamidoethyl)benzoic acid 

Relevant articles and documents

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro deriv

Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-α suppression and IL-10 augmentation

A series of arylpiperazine derivatives was synthesized to obtain agents showing apparent therapeutic effects in a chronic inflammatory animal model, starting from a lead possessing potent dual cytokine regulatory activity in vivo. We found a pyrimidylpipe