67230-92-6

Upstream product

• 79-35-6 1,1'-dichloro-2,2'-difluoroethene 
• 100-52-7 benzaldehyde 
• 103654-96-2 1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 754-17-6 1-chloro-1,1-dibromotrifluoroethane 
• 306-83-2 1,1,1-trifluoro-2,2-dichloroethane 
• 151-67-7 1,1,1-trifluoro-2-bromo-2-chloroethane 
• 75-88-7 1,1,1-trifluoro-2-chloroethane 
• 359-10-4 1-Chloro-2,2-difluoroethene 
• 109-72-8 n-butyllithium 

Downstream Products

• 108377-23-7 ((Z)-2,3-Dichloro-3,3-difluoro-propenyl)-benzene 
• 34093-70-4 (Z)-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 

Relevant academic research and scientific papers

Reaction of halothane with carbonyl compounds in the presence of bases

The reaction of halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane (1), with aldehydes and ketones in the presence of bases was found to give 1-alkyl- or 1-aryl-2-bromo-2-chloro-3,3, 3-trifluoropropanols (2) or 2-chloro-3,3-difluoro-2-propenols (3) selecti

Efficient, practical and reproducible reactions of a commercial hydrochlorofluorocarbon

We report a reliable and reproducible procedure for the conversion of readily-available hydrochlorofluorocarbon 1-chloro-2,2,2-trifluoroethane (HCFC-133a) to a metallated difluoroalkene (1-chloro-1-lithio-2,2-difluoroethene) which can be trapped with a range of electrophiles to afford high isolated yields of products. 1-Chloro-1-lithio-2,2-difluoroethene generated by our method reacts efficiently with aldehydes and ketones, Group (IV) halides, an epoxide and a sulfur electrophile. Less reactive, softer electrophiles fail to trap the reactive intermediate.

Synthesis of fluorine compounds using zinc complex of halothane

We have reported the Grignard reaction of Halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane (1), with ketones gave unexpected products, α-(1-bromo-1-chloro-2,2,2-trifluoroethyl)alcohols (4) at a low temperature. However, this reaction hardly proceeded with aldehydes. Now, we found the reaction of 1 with aldehydes in the presence of zinc gave not only products of type 4, but α-(1-chloro-2,2,2-trifluoroethyl)alcohols (3), the expected type of products, under mild conditions in good to moderate yields.

A method for synthesis of fluorine compounds using abnormal Grignard reaction of halothane. II. Reaction with aldehydes and unsaturated ketones

In an abnormal Grignard reaction of halothane, the primary Grignard reagent reacts with another mole of halothane to give 1-bromo-1-chloro- 2,2,2-trifluoroethylmagnesium bromide, which in turn reacts with a carbonyl compound to give 1-bromo-1-chloro-2,2,2

Synthetic utility of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane): the reaction between HCFC-123 and aldehydes using zinc

HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) reacted with zinc and aldehydes to afford predominantly either 1-substituted 2-chloro-3,3-difluoro-2-propen-1-ols or 1-substituted 2,2-dichloro-3,3,3-trifluoro-1-propanols.The reactions proceeded via 1,1-dichloro-2,2,2-trifluoroethylzinc chloride as an organozinc intermediate. - Keywords: 2,2-Dichloro-1,1,1-trifluoroethane; Reaction; Aldehydes; Zinc; 1,1-Dichloro-2,2,2-trifluoroethylzinc chloride

Electroreductive coupling of halofluoro compounds with aldehydes

Electroreductive intermolecular coupling of halofluoro compounds such as 1,1,1-trichloro-2,2,2-trifluoroethane, methyl chlorodifluoroacetate, and perfluoroalkyl halides with aldehydes took place effectively in the presence of chlorotrimethylsilane and one of the coupling products, 2,2-dichloro-3,3,3-trifluoro-1-phenyl-1-propranol, was selectively convertible to a variety of compounds with using the electroreduction as a key reaction.

Facile Conversion of Aldehydes into 1-Substituted 2-Chloro-3,3-difluoro-2-propen-1-ols with 1,1-Dibromo-1-chloro-2,2,2,-trifluoroethane/Magnesium Reagent

Aldehydes RCHO are converted in excellent yields into chlorodifluoroallyl alcohols RCH(OH)CCl=CF2 upon treatment with CClBr2CF3 and magnesium in tetrahydrofuran at 0 deg C.

Efficient Carbonyl Addition of Polyfluorochloroethyl, -ethylidene, and -ethenyl Units by Means of 1,1,1-Trichloro-2,2,2-trifluoroethane and Zinc

Thermally stable zinc carbenoid CF3CCl2ZnCl was prepared from 1,1,1-trichloro-2,2,2-trifluoroethane and zinc powder in N,N-dimethylformamide and was allowed to add to carbonyls of aldehydes and α-keto esters in excellent yields to give 1-substituted 2,2-d

PRACTICAL WAYS FROM ALDEHYDES TO 2-CHLORO-1,1,1-TRIFLUORO-2-ALKENES AND 2-CHLORO-1,1-DIFLUORO-1-ALKEN-3-OLS

A reagent system CF3CCl3/Zn(>2 mol)/Ac2O transformed aldehydes to 2-chloro-1,1,1-trifluoro-2-alkenes exclusively, whereas CF3CCl3/Zn(>2 mol)/AlCl3(cat.) converted aldehydes into 2-chloro-1,1-difluoro-1-alken-3-ols.