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Usage

Uses

Used in Pharmaceutical Synthesis:
4-(1,3-THIAZOL-2-YL)BENZONITRILE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and properties allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-(1,3-THIAZOL-2-YL)BENZONITRILE serves as a crucial component in the creation of pesticides and other agrochemicals. Its incorporation can lead to the development of more effective and targeted products for agricultural use.
Used in Organic Electronic Devices:
4-(1,3-THIAZOL-2-YL)BENZONITRILE is also being investigated for its potential use in organic electronic devices. Its electronic properties make it a promising candidate for applications such as organic light-emitting diodes (OLEDs) and organic solar cells, where it can contribute to improved performance and efficiency.
Overall, 4-(1,3-THIAZOL-2-YL)BENZONITRILE is a valuable compound with diverse applications across multiple industries, including pharmaceuticals, agrochemicals, and organic electronics. Its versatility and potential for further research and development make it an important player in the field of organic synthesis.

InChI:InChI=1/C10H6N2S/c11-7-8-1-3-9(4-2-8)10-12-5-6-13-10/h1-6H

Upstream product

• 288-47-1 1,3-thiazole 
• 623-03-0 4-Cyanochlorobenzene 
• 623-00-7 4-bromobenzenecarbonitrile 
• 121359-48-6 2-(tri-n-butylstannyl)thiazole 
• 5053-24-7 2-methylthio-1,3-thiazole 
• 3058-39-7 4-iodobenzonitrile 
• 623-26-7 terephthalonitrile 
• 3034-53-5 2-bromo-1,3-thiazole 
• 126747-14-6 4-cyanophenylboronic acid 

Downstream Products

• 1026500-07-1 4-{5-[2-Chloro-1-(2,4-difluoro-phenyl)-1-hydroxy-ethyl]-thiazol-2-yl}-benzonitrile 
• 1234444-57-5 5-bromo-2-(4-cyanophenyl)thiazole 
• 170863-69-1 1-(2,4-difluorophenyl)-1-{2-[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]thiazol-2-yl}-2-(1H-1,2,4-triazol-1-yl)ethanol 
• 170863-68-0 1-(2,4-difluorophenyl)-1-[4-(4-cyanophenyl)thiazol-5-yl]-2-(1H-1,2,4-triazol-1-yl)ethanol 

Relevant academic research and scientific papers

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

THIAZOLE AND OXAZOLE KINASE INHIBITORS

The present invention is concerned with substituted azole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. In particular, several of these compounds are potent and selective Flt-3 inhibitors or/and syk inhibitors.

Cobalt-catalyzed C-SMe bond activation of heteroaromatic thioethers

Cobalt-catalyzed activation of methylthio-substituted N-heterocycles facilitates either cross-coupling reactions with aryl- or benzylzinc compounds or synthesis of the corresponding zinc compounds.

Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles

Seven novel diamidino 2,5-bis(aryl)thiazoles (5a-g) were synthesized and evaluated against Trypanosoma brucei rhodensiense (T. b. r.) and Plasmodium falciparum (P. f.). The diamidines were obtained directly from the corresponding bis-nitriles (4a-g) by th

Pd-PEPPSI-IPent: Low-temperature negishi cross-coupling for the preparation of highly functionalized, tetra-ortho-substituted biaryls

(Chemical Equation Presented) Cool couplings: Complex, hindered biaryls have been prepared at temperatures ranging from 0°C to room temperature, or with gentle heating. The Pd-PEPPSI-IPent catalyst (see scheme) nicely couples starting materials containing acidic moieties and routinely prepares biaryl derivatives where one or both rings comprising the biaryl are heterocyclic. Ar1=hindered aryl or heteroaryl, Ar2=unactivated aryl or heteroaryl.