67274-48-0

Basic information

• Product Name: N-(4-bromophenyl)-N-hydroxyacetamide
• Synonyms: acetamide, N-(4-bromophenyl)-N-hydroxy-; N-(4-Bromophenyl)-N-hydroxyacetamide
• CAS NO: 67274-48-0
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.0586
• Mol File: 67274-48-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 341°C at 760 mmHg
• Flash Point: 160°C
• Density: 1.664g/cm³
• Vapor Pressure: 3.21E-05mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: N-(4-bromophenyl)-N-hydroxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)-N-hydroxyacetamide(67274-48-0)
• EPA Substance Registry System: N-(4-bromophenyl)-N-hydroxyacetamide(67274-48-0)

Safety Data

• Hazardous Substances Data: 67274-48-0(Hazardous Substances Data)

Upstream product

• 14454-14-9 N-(4-iodophenyl)hydroxylamine 
• 75-36-5 acetyl chloride 
• 636-98-6 p-nitrobenzene iodide 
• 106-40-1 4-bromo-aniline 
• 3623-23-2 4-bromonitrosobenzene 
• 113-24-6 sodium pyruvate 
• 431-03-8 dimethylglyoxal 
• 586-78-7 para-nitrophenyl bromide 
• 1795-83-1 N-Phenylacetohydroxamic acid 
• 10468-46-9 N-(4-bromophenyl)hydroxylamine 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 91631-56-0 N-sulfonoxy-p-bromoacetanilide pyridinium salt 
• 1373442-24-0 (E)-methyl 3-(2-acetamido-5-bromophenyl)acrylate 
• 175278-18-9 N-(4-bromo-2-(trifluoromethoxy)phenyl)acetamide 

Relevant articles and documents

Transketolase Catalyzed Synthesis of N-Aryl Hydroxamic Acids

Hydroxamic acids are metal-chelating compounds that show important biological activity including anti-tumor effects. We have recently engineered the transketolase from Geobacillus stearothermopilus (TKgst) to convert benzaldehyde as a non-natur

TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION

The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: (I), wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is -H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), - (alkylaryl), - (alkylheteroaryl), -NH-(alkyl), -N(alkyl)2, -NH-(alkenyl), -NH-(alkynyl) -NH-(aryl), -NH-(heteroaryl), -O-(alkyl), -O-(alkenyl), -O-(alkynyl), -O-(aryl), -O-(heteroaryl), -S-(alkyl), -S- (alkenyl), -S-(alkynyl), -S-(aryl), or -S-(heteroaryl), comprising: (a) reacting a compound having the structure: (II), with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: (III); and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure: (I).

Rhodium(III)-catalyzed internal oxidative coupling of N-hydroxyanilides with alkenes via C-H activation

Abstract Described herein is an efficient new method for ortho-olefination of anilides in the presence of AgSbF6 and NaOAc via rhodium(III)-catalyzed internal oxidative C-H bond activation based on hydroxyl as directing and oxidative group. A range of alkenes and functional groups on acetanilides is supported and a possible mechanism is proposed according to the experimental results.