67319-83-9

Basic information

• Product Name: AcetaMide, 2,2,2-trifluoro-N-[4-(trifluoroMethyl)phenyl]-
• Synonyms: AcetaMide, 2,2,2-trifluoro-N-[4-(trifluoroMethyl)phenyl]-
• CAS NO: 67319-83-9
• Molecular Formula: C₉H₅F₆NO
• Molecular Weight: 257.1325192
• Mol File: 67319-83-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 249.6°Cat760mmHg
• Flash Point: 104.8°C
• Appearance: /
• Density: 1.491g/cm³
• Vapor Pressure: 0.0227mmHg at 25°C
• Refractive Index: 1.445
• CAS DataBase Reference: AcetaMide, 2,2,2-trifluoro-N-[4-(trifluoroMethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, 2,2,2-trifluoro-N-[4-(trifluoroMethyl)phenyl]-(67319-83-9)
• EPA Substance Registry System: AcetaMide, 2,2,2-trifluoro-N-[4-(trifluoroMethyl)phenyl]-(67319-83-9)

Safety Data

• Hazardous Substances Data: 67319-83-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H5F6NO/c10-8(11,12)5-1-3-6(4-2-5)16-7(17)9(13,14)15/h1-4H,(H,16,17)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 407-25-0 trifluoroacetic anhydride 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 2926-29-6 Langlois reagent 
• 214360-65-3 4-trifluoromethylphenylboronic acid pinacol ester 
• 77152-08-0 trifluoromethylcopper(I) 
• 126063-08-9 2,2,2-trifluoro-N-(4-iodophenyl)acetamide 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 1416701-99-9 4-hydroxy-5-methoxy-N-trideuteriomethyl-1-methyl-2-oxo-N-[(4-trifluoromethyl)phenyl]-1,2-dihydroquinoline-3-carboxamide 
• 1416702-01-6 2,2,2-trifluoro-N-trideuteriomethyl-N-(4-trifluoromethyl-phenyl)-acetamide 

Relevant articles and documents

Preparation method of perfluoroalkylated aryl compound

The present invention provides a process for the preparation of a perfluoroalkylated aryl compound which comprises reacting an aryl compound with a perfluoroalkylsulfinate in the presence of an iron salt and hydrogen peroxide. To the method provided by the invention, perfluoroalkyl sulfinate is used as an alkylating agent, iron salt is used as a catalyst, hydrogen peroxide is used as an initiator, and the reaction time is short. The method has the characteristics of high yield, convenient operation, high safety and the like, and has wide application in the fields of drug synthesis, biological probes, fluorescent materials and the like.

Amination reagent as well as preparation method and application thereof

The invention discloses an amination reagent as well as a preparation method and application thereof. The amination reagent has a structure as shown in a formula disclosed in the invention, wherein Xis selected from any one of I, Cl, Br, NO3 and ClO4, and Y and Z are independently selected from H or alkyl with the carbon atom number of 1-4. The process for preparing the amination reagent is simple, the raw materials are easy to obtain, the cost is low, the yield is stable, and the prepared amination reagent is stable in character, can be stored at room temperature for a long time and can be taken as needed; meanwhile, the prepared amination reagent is efficient in performance, boron substrate applicability is excellent, reaction effect is good, and limitation of amination reaction of organic boron compounds on substrates is greatly expanded.

Aryl Sulfonium Salts for Site-Selective Late-Stage Trifluoromethylation

Incorporation of the CF3 group into arenes has found increasing importance in drug discovery. Herein, we report the first photoredox-catalyzed cross-coupling of aryl thianthrenium salts with a copper-based trifluoromethyl reagent, which enables a site-selective late-stage trifluoromethylation of arenes. The reaction proceeds with broad functional group tolerance, even for complex small molecules on gram scale. The method was further extended to produce pentafluoroethylated derivatives.