67335-29-9

Upstream product

• 50-00-0 formaldehyd 
• 3558-24-5 1-methyl-2-phenyl-1H-indole 
• 78395-78-5 1-methyl-2-phenyl-3-hydroxymethylindole 
• 7732-18-5 water 
• 1634-04-4 tert-butyl methyl ether 
• 127-19-5 N,N-dimethyl acetamide 
• 1757-72-8 1-methyl-2-phenyl-1H-indole-3-carbaldehyde 
• 948-65-2 2-phenyl-indole 

Downstream Products

• 78395-79-6 1-methyl-3,4-dinitro-2-phenylindole 
• 78395-73-0 1-methyl-2-phenyl-3,6-dinitroindole 
• 78395-71-8 1-methyl-2-phenyl-3-nitro-1H-indole 
• 78395-75-2 3-(4-nitrophenyldiazenyl)-1-methyl-2-phenyl-1H-indole 

Relevant academic research and scientific papers

Synthesis of Unnatural Arundines Using a Magnetically Reusable Copper Ferrite Catalyst

We report a method for copper ferrite-catalyzed coupling of indoles and N, N -dimethylacetamide (DMA) to afford Arundine derivatives. Halogen, methoxy, boronate ester, and trimethylsilyl functionalities are compatible with reaction conditions. Unprotected or sterically hindered indoles are also competent substrates. Indoles containing competitively reactive pyrazoles deliver the desired products in reasonable yields. The copper ferrite is easily recovered and reused, up to nine times without a significant yield loss.

Selectfluor facilitated bridging of indoles to bis(indolyl)methanes using methyl: Tert -butyl ether as a new methylene precursor

A novel, green and efficient method is developed for the synthesis of methylene bridged bis(indolyl)methanes in good to excellent yields. The reaction employs methyl tert-butyl ether (MTBE) as the methylene source and selectfluor as an oxidizing agent. The scope and versatility of the methods have been successfully demonstrated with 48 examples. The metal-free transformation process is suitable for scale-up production. A selectfluor-promoted oxidative reaction mechanism is proposed based on the results of the experimental studies. This journal is