675882-81-2

Basic information

• Product Name: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[4-methyl-6-(7-methyl-2-benzoxazolyl)-2-propyl-1H-benzimidazol-1-yl ]methyl]-, methyl ester
• CAS NO: 675882-81-2
• Molecular Formula: C34H31N3O3
• Molecular Weight: 529.638
• Mol File: 675882-81-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[4-methyl-6-(7-methyl-2-benzoxazolyl)-2-propyl-1H-benzimidazol-1-yl ]methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[4-methyl-6-(7-methyl-2-benzoxazolyl)-2-propyl-1H-benzimidazol-1-yl ]methyl]-, methyl ester(675882-81-2)
• EPA Substance Registry System: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[4-methyl-6-(7-methyl-2-benzoxazolyl)-2-propyl-1H-benzimidazol-1-yl ]methyl]-, methyl ester(675882-81-2)

Safety Data

• Hazardous Substances Data: 675882-81-2(Hazardous Substances Data)

Upstream product

• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 885046-11-7 7-methyl-2-(4-methyl-2-propyl-1H-benzo[d]imidazol-6-yl)benzo[d]oxazole 
• 152628-01-8 4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester 
• 675882-71-0 3-methyl-4-butyrylamino-5-aminobenzoic acid methyl ester 
• 152628-00-7 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester 
• 301533-59-5 methyl 4-(n-butyrylamino)-3-methylbenzoate 
• 152628-03-0 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid 
• 78886-51-8 2-methyl-6-aminophenol hydrochloride 
• 24078-21-5 methyl 3-methyl-4-nitrobenzoate 
• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 

Relevant articles and documents

Facile Synthesis of Novel Nonpeptide Angiotensin II Receptor Antagonists

A series of Losartan analogues 1-12 with different functional groups were synthesized and characterized. In comparison with the previous reports, the synthetic procedures described in this paper have been optimized as follows below: 1) preparation of aromatic amine 15 and 18 through hydrogenation by employing Raney Ni and hydrazine as catalysts in place of palladium; 2) preparation of nitro-compound 17 by using pure fuming nitric acid at -20 - -15°C; 3) alkylation of 21 with 22 or 23 in the presence of sodium hydride in place of potassium tert-butylate; 4) preparation of carboxylic acid 4 by ester cleavage rather than hydrolysis of cyano group.