677-24-7

Basic information

• Product Name: METHYL PHOSPHORODICHLORIDATE
• Synonyms: Methoxyphosphorylchloride;Methyl dichloridophosphate;(Phosphoric acid methyl) dichloride;Dichloridophosphoric acid methyl ester;Dichlorophosphinic acid methyl ester;Methyl phosphoric dichloride;Methyl dichlorophosphate,97%;Methy
• CAS NO: 677-24-7
• Molecular Formula: CH₃Cl₂O₂P
• Molecular Weight: 148.91
• EINECS: 211-639-1
• Product Categories: Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Phosphorylation;Protecting Agents, Phosphorylating Agents & Condensing Agents;Synthetic Organic Chemistry
• Mol File: 677-24-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: -59 °C
• Boiling Point: 62-64 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.488 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.21mmHg at 25°C
• Refractive Index: n20/D 1.436(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL PHOSPHORODICHLORIDATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL PHOSPHORODICHLORIDATE(677-24-7)
• EPA Substance Registry System: METHYL PHOSPHORODICHLORIDATE(677-24-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 677-24-7(Hazardous Substances Data)

Usage

Chemical Description

Methyl phosphorodichloridate is a chemical compound with the formula CH3POCl2.

Uses

Methyl dichlorophosphate was used in the synthesis of:4,6-cyclic phosphate tetrasaccharide8-(2′′-hydroxyethoxy)adenosine-5′,2′′-phosphate derivativeanalogs of (R)-1-O-hexadecyl-2-palmitoyl-sn-glycero-3-phosphoethanolamine poly(ethylene glycol)dioxaphosphorino[m,n-x]pyridines compounds

InChI:InChI=1/CH3Cl2O2P/c1-5-6(2,3)4/h1H3

Upstream product

• 54262-51-0 O-methyl O-phenyl S-propyl thiophosphate 
• 152-20-5 O,O,S-trimethyl phosphorothioate 
• 23272-12-0 methoxydimethylsilyl cyanide 
• 6840-11-5 phenylthiophosphonic acid dimethyl ester 
• 5314-03-4 O,O-Dimethyl-O-(p-chlorphenyl)-thiophosphat 
• 33576-92-0 O,O-dimethyl O-phenyl phosphorothioate 
• 67-56-1 methanol 

Downstream Products

• 34704-85-3 C₁₁H₁₃N₂O₄P 
• 18891-27-5 dimethyl 4,4'-((methoxyphosphoryl)bis(oxy))dibenzoate 
• 1123194-95-5 (E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]acrylonitrile 
• 1106864-23-6 2-methoxy-6-phenyl-1,2-dihydro-2λ5-[1,2,4]triazolo[4,3-d][1,3,4,2]thiadiazaphosphol-2-one 
• 1095623-93-0 tert-butyldimethylsilyl (2E)-3-[4-(chloromethoxyphosphoryloxy)phenyl]acrylate 

Relevant articles and documents

The chlorination reaction of O-alkyl S-alkyl(aryl) thiophosphoric(-nic) acid derivatives with phosphorus oxychloride

It is reported that a variety of O-alkyl S-alkyl(aryl) thiophosphoric(-nic) acid derivatives 4 can be readily chlorinated with phosphorus oxychloride giving S-alkyl(aryl) thiophosphoro(-no)chloridates 2 and O-alkyl phosphorodichloridates 3.

ORGANOSILICON AND ORGANOPHOSPHORUS COMPOUNDS WITH PSEUDOHALIDE GROUPS 3. REACTIONS OF ALKOXYDIMETHYLSILYL CYANIDES WITH TETRACOORDINATED PHOSPHORUS HALIDES

The reactions of alkoxydimethylsilyl cyanides with some tetracoordinated phosphorus chlorides and fluorides were investigated.It was shown that the investigated reactions are realized primarily with the replacement of two halogen atoms by functional groups.The transformations of the phosphorus acid cyanides obtained with metal fluorides were studied. Keywords: silyl cyanides, phosphorus(IV) halides, substitution reactions, metal fluorides.