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68195-63-1

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68195-63-1 Usage

Description

Edaravone is a medication with neuroprotective properties, primarily used for the treatment of acute cerebral infarction and amyotrophic lateral sclerosis (ALS). It functions by eliminating free radicals and reducing oxidative stress, which are significant factors contributing to neuronal damage.

Uses

Used in Pharmaceutical Industry:
Edaravone is used as an intravenous medication for the treatment of acute cerebral infarction, aiming to facilitate recovery following a stroke by reducing neuronal damage and oxidative stress.
Additionally, Edaravone is used as an oral medication for the treatment of amyotrophic lateral sclerosis (ALS), where it helps to slow the progression of the disease by protecting neurons from oxidative stress and free radical damage.

Check Digit Verification of cas no

The CAS Registry Mumber 68195-63-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,1,9 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 68195-63:
(7*6)+(6*8)+(5*1)+(4*9)+(3*5)+(2*6)+(1*3)=161
161 % 10 = 1
So 68195-63-1 is a valid CAS Registry Number.

68195-63-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,4-Bis-(3-methyl-phenyl-pyrazolin-5-on-4-yl)-3-methyl-1-phenyl-pyrazolin-5-on

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:68195-63-1 SDS

68195-63-1Downstream Products

68195-63-1Relevant articles and documents

Accidental synthesis of a trimer of pyrazolone and comparison of its antioxidant activity: an investigatory report

Jain, Arti,Malhotra, Priti,Yadav, Sushma

, (2021)

Abstract: Untargeted synthesis leading to the formation of a significant product is a common practice and has been successfully achieved after holistic characterization of the accidentally formed molecule of the trimer of pyrazolone. Its significance was further explored in the pharmaceutical field emphasizing the need for the synthesis and validating the newly established pathways for its synthesis. It was known that pyrazolone exhibit a plethora of applications ranging from catalysis, decolourisation of dyes and metallurgical extractions. Paramount importance has been attributed to pyrazolones in recent years for their broad-spectrum biological activities manifested in their anti-inflammatory, analgesic, anticancer and anti-tubercular functions. In the ongoing research 4,4-Bis-(3-methyl-phenyl-pyrozolin-5-on-4-yl)-3-methyl-1-phenyl-pyrzolin-5-one was synthesized economically and efficiently via a novel one-step bio-catalytic pathway using laccase as a catalyst. To validate the utility of our accidental discovery, we have also calculated its antioxidant activity against ascorbic acid as a standard compound. DPPH and ABTS have been used to study the scavenging of free radicals in-vitro. This is the first report of the enzyme driven synthesis of trimeric form of pyrazolone. These results will emphasise the utilization of pyrazolone trimers as eco-friendly compounds which exhibit a promising natural antioxidant property in physiological environments. Graphic abstract: An investigatory report is being presented featuring a novel eco-friendly pathway for the synthesis of trimeric of pyrazolone i.e., 4,4-Bis-(3-methyl-phenyl-pyrozolin-5-on-4-yl)-3-methyl-1-phenyl-pyrzolin-5-one. The trimeric form of the molecule possesses spiked antioxidant properties verified by DPPH and ABTS assays. Thus, this work opens new frontiers for further research in this direction.[Figure not available: see fulltext.]

Free Radical Reactions of N-Heterocyclic Compounds. XI. Reaction of 3-Methyl-pyrazolin-5-ones with Phenoxy Radicals

Schulz, Manfred,Meske, Michael

, p. 607 - 615 (2007/10/02)

Pyrazolin-5-ones (3a-i) were oxidized with 2,4,6-trisubstituted phenoxy radicals (2a-d) to the corresponding radicals (4a-i), which dimerised or combined with phenoxy radical (2a) depending on the R1- and R4-substituents in (3).In th

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