68195-63-1Relevant articles and documents
Accidental synthesis of a trimer of pyrazolone and comparison of its antioxidant activity: an investigatory report
Jain, Arti,Malhotra, Priti,Yadav, Sushma
, (2021)
Abstract: Untargeted synthesis leading to the formation of a significant product is a common practice and has been successfully achieved after holistic characterization of the accidentally formed molecule of the trimer of pyrazolone. Its significance was further explored in the pharmaceutical field emphasizing the need for the synthesis and validating the newly established pathways for its synthesis. It was known that pyrazolone exhibit a plethora of applications ranging from catalysis, decolourisation of dyes and metallurgical extractions. Paramount importance has been attributed to pyrazolones in recent years for their broad-spectrum biological activities manifested in their anti-inflammatory, analgesic, anticancer and anti-tubercular functions. In the ongoing research 4,4-Bis-(3-methyl-phenyl-pyrozolin-5-on-4-yl)-3-methyl-1-phenyl-pyrzolin-5-one was synthesized economically and efficiently via a novel one-step bio-catalytic pathway using laccase as a catalyst. To validate the utility of our accidental discovery, we have also calculated its antioxidant activity against ascorbic acid as a standard compound. DPPH and ABTS have been used to study the scavenging of free radicals in-vitro. This is the first report of the enzyme driven synthesis of trimeric form of pyrazolone. These results will emphasise the utilization of pyrazolone trimers as eco-friendly compounds which exhibit a promising natural antioxidant property in physiological environments. Graphic abstract: An investigatory report is being presented featuring a novel eco-friendly pathway for the synthesis of trimeric of pyrazolone i.e., 4,4-Bis-(3-methyl-phenyl-pyrozolin-5-on-4-yl)-3-methyl-1-phenyl-pyrzolin-5-one. The trimeric form of the molecule possesses spiked antioxidant properties verified by DPPH and ABTS assays. Thus, this work opens new frontiers for further research in this direction.[Figure not available: see fulltext.]
Free Radical Reactions of N-Heterocyclic Compounds. XI. Reaction of 3-Methyl-pyrazolin-5-ones with Phenoxy Radicals
Schulz, Manfred,Meske, Michael
, p. 607 - 615 (2007/10/02)
Pyrazolin-5-ones (3a-i) were oxidized with 2,4,6-trisubstituted phenoxy radicals (2a-d) to the corresponding radicals (4a-i), which dimerised or combined with phenoxy radical (2a) depending on the R1- and R4-substituents in (3).In th