6828-55-3

Upstream product

• 536-40-3 4-chlorobenzoic acid hydrazide 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 613-94-5 benzoic acid hydrazide 
• 74-11-3 para-chlorobenzoic acid 
• 155164-66-2 2-benzoyl-4,5-dichloropyridazin-3(2H)-one 
• 450408-66-9 4,5-dichloro-2-(4-chloro-benzoyl)-2H-pyridazin-3-one 

Downstream Products

• 1156534-46-1 2-(4-chlorophenyl)-5-phenyl-1,3,4-selenadiazole 
• 471910-33-5 3-(4-chlorophenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 87277-53-0 3-(4-chlorophenyl)-5-phenyl-1H-1,2,4-triazole 
• 87277-51-8 1-methyl-5-(4-chlorophenyl)-3-phenyl-1H-1,2,4-triazole 
• 87277-52-9 3-(4-Chloro-phenyl)-1-methyl-5-phenyl-1H-[1,2,4]triazole 
• 10465-84-6 4-Chlor-azodibenzoyl 
• 106-47-8 4-chloro-aniline 
• 62-53-3 aniline 
• 1874-43-7 2-(4-chlorophenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant academic research and scientific papers

One-Pot Catalytic Approach for the Selective Aerobic Synthesis of Imines from Alcohols and Amines Using Efficient Arene Diruthenium(II) Catalysts under Mild Conditions

A green and efficient catalytic approach for the selective synthesis of imines in air at room temperature was achieved with the aid of newly synthesised diruthenium(II) complexes [(η6-p-cymene)2Ru2Cl2(μ-L)] containing substituted 1,2-diacylhydrazine ligands. All the new complexes were fully characterised by analytical and spectroscopic techniques. The solid-state structure of a representative complex was solved by single-crystal X-ray diffraction analysis. The diruthenium(II) complexes also enable the selective aerobic oxidation of alcohols to aldehydes. The catalytic reaction operates in the presence of air as a green and cheap oxidant, and releases water as the only by-product. A plausible mechanism is proposed for the imine formation, which is believed to proceed via an aldehyde intermediate.

In situ generated cetyltrimethylammonium bisulphate in choline chloride-urea deep eutectic solvent: A novel catalytic system for one pot synthesis of 1,3,4-oxadiazole

Cetyltrimethylammonium bisulphate ([CTA]HSO4) catalysed one pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles from carboxylic acid and acid hydrazide in biodegradable deep eutectic solvent is investigated. [CTA]HSO 4 is generated in situ from cetyltrimethylammonium peroxodisulphate. Cyclization of diacylhydrazide using [CTA]HSO4 gives best alternative to traditional dehydration agents. Its remarkable features include a milder procedure, simplicity in workup and purification, good to excellent yields of products, use of inexpensive, recyclable reagents, and eco-friendly aspects by avoiding toxic catalysts/reagents and solvents. Graphical Abstract: [Figure not available: see fulltext.].

17O NMR studies of substituted 1,3,4-oxadiazoles

Three series of substituted 1,3,4-oxadiazoles were studied by 17O NMR spectroscopy. Chemical shifts values were correlated with empirical Hammett parameters as well as calculated bond lengths and chemical shielding values.

Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles

A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted- 1,3,4-oxadiazoles in good to very good yields.

Facile synthesis of symmetric and unsymmetric 1,3,4-oxadiazoles using 2-acyl(or aroyl)pyridazin-3-ones

Symmetric and unsymmetric 1,3,4-oxadiazoles were synthesized in situ from hydrazine hydrate and the corresponding 2-acyl-4,5-dichloropyridazin-3-ones as acylating agents in polyphosphoric acid or BF3·OEt2 in excellent yields.

Hypervalent iodine oxidation of acid hydrazides: A new synthesis of N,N'-diacylhydrazines

Hypervalent iodine oxidation of p-substituted benzohydrazides (1a-h), phenylacetohydrazide (1i) and heterocyclic acid hydrazides (1j-l) using one equivalent of iodobenzene diacetate in dry dichloromethane or acetonitrile leads to dimerization thereby providing a new and facile method for the synthesis of N,N-diacylhydrazines 2.