68295-47-6

Basic information

• Product Name: 2-Pyrrolidinecarboxamide, 5-oxo-N-phenyl-, (2S)-
• CAS NO: 68295-47-6
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.228
• Mol File: 68295-47-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinecarboxamide, 5-oxo-N-phenyl-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinecarboxamide, 5-oxo-N-phenyl-, (2S)-(68295-47-6)
• EPA Substance Registry System: 2-Pyrrolidinecarboxamide, 5-oxo-N-phenyl-, (2S)-(68295-47-6)

Safety Data

• Hazardous Substances Data: 68295-47-6(Hazardous Substances Data)

Upstream product

• 56-86-0 L-glutamic acid 
• 62-53-3 aniline 
• 511543-55-8 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octane-4,8-dione 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 450-99-7 N¹-phenyl-N²-trifluoroacetyl-L-isoglutamine 
• 62121-04-4 N¹-phenyl-L-isoglutamine 

Downstream Products

• 1206890-78-9 (S)-5-oxo-N-phenyl-1-((E)-3-phenylacryloyl)pyrrolidine-2-carboxamide 
• 232618-88-1 (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane 
• 609799-33-9 (S)-[(4-bromophenylamino)methyl]pyrrolidine 
• 879899-84-0 N,N-diisopropyl-2-formyl-6-[(2'R,4'S)-2-phenylperhydropyrrolo-(1,2c)-imidazol-3-yl]benzamide 
• 609799-32-8 (2S)-5-oxo-2-(4-bromoanilinocarbonyl)pyrrolidine 
• 64030-44-0 (2S)-2-(anilinomethyl)pyrrolidine 

Relevant articles and documents

L-Pyroglutamic Sulphonamide as Hydrogen-Bonding Organocatalyst: Enantioselective Diels-Alder Cyclization to Construct Carbazolespirooxindoles

Hydrogen-bonding organocatalysts L-pyroglutamic sulphonamides were readily synthesized for the first time by fully exploiting the potentials of L-pyroglutamic acid. The newly designed catalyst was successfully applied in catalyzing asymmetric Diels-Alder

Discovery of highly functionalized scaffolds: Pyrroloimidazolediones as P2X7 receptor antagonists

A broad range of pyrroloimidazolediones, new highly functionalized bicyclic heterocycles, was obtained by a cycloaddition reaction between L-pyroglutamide derivatives and Bredereck's reagent. Methanolysis of subsequent pyrroloimidazolediones provided antagonists of P2X7 receptor, with retention of initial stereoconfiguration, with potential applications in the treatment of inflammatory and neurological diseases. We have thus developed a new synthesis of lactamic nitrogen free enaminones which is currently the easiest method cited in the literature to access these compounds.

Michael addition reactions between various nucleophilic glycine equivalents and (S,E)-1-enoyl-5-oxo-N-phenylpyrrolidine-2-carboxamide, an optimal type of chiral Michael acceptor in the asymmetric synthesis of β-phenyl pyroglutamic acid and related compoun

(S)-5-Oxo-N-phenyl-1-[(E)-3-phenylacryloyl]pyrrolidine-2-carboxamide, easily prepared from inexpensive and readily available, in both enantiomeric forms, glutamic/pyroglutamic acid was designed as an optimal type of chiral Michael acceptor for reactions w