6831-56-7

Basic information

• Product Name: 2',3'-dimethoxyphenylacetyl chloride
• Synonyms: 2',3'-dimethoxyphenylacetyl chloride
• CAS NO: 6831-56-7
• Molecular Weight: 214.649
• Mol File: 6831-56-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2',3'-dimethoxyphenylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-dimethoxyphenylacetyl chloride(6831-56-7)
• EPA Substance Registry System: 2',3'-dimethoxyphenylacetyl chloride(6831-56-7)

Safety Data

• Hazardous Substances Data: 6831-56-7(Hazardous Substances Data)

Upstream product

• 3893-01-4 2,3-dimethoxybenzyl chloride 
• 4468-57-9 2-(2,3-dimethoxyphenyl)acetonitrile 
• 90-53-9 2,3-dimethoxyphenylacetic acid 

Downstream Products

• 796074-04-9 (2,3-dimethoxy-phenyl)-acetic acid-(2,3-dimethoxy-phenethylamide) 
• 855647-68-6 1-(α-bromo-3,4-dimethoxy-benzyl)-5,6-dimethoxy-isoquinoline 
• 10313-65-2 (5,6-dimethoxy-3,4-dihydro-[1]isoquinolyl)-(3,4-dimethoxy-phenyl)-ketone 
• 855617-40-2 (5,6-dimethoxy-[1]isoquinolyl)-(3,4-dimethoxy-phenyl)-ketone 
• 48208-75-9 5,6-dimethoxy-1-veratryl-isoquinoline 
• 59276-10-7 5,6-dimethoxy-1-veratryl-3,4-dihydro-isoquinoline 
• 10313-64-1 N-(2,3-dimethoxyphenylethyl)-2-(3,4-dimethoxyphenyl)acetamide 
• 3213-29-4 2,3-dimethoxyphenethylamine 
• 6957-27-3 3,4-dihydropapaverine 
• 28033-71-8 N-Butyl-2-(2,3-dimethoxy-phenyl)-acetamide 
• 28033-67-2 2-(2,3-Dimethoxy-phenyl)-N-isopropyl-acetamide 
• 5663-55-8 (2,3-dimethoxy-phenyl)-acetic acid amide 
• 1446442-33-6 2-(6-iodo-2,3-dimethoxyphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]acetamide 
• 1446442-72-3 2-(2,3-dimethoxyphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]acetamide 

Relevant articles and documents

Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle

The mechanism of relaxant activity of six benzylisoquinolines was examined in order to determine the minimal structural requirements that enable these compounds to have either a non-specific action like papaverine or an inhibitory activity on calcium entry via potential-operated channels. All the alkaloids tested totally or partially relaxed KCl-depolarized rat uterus and inhibited oxytocin-induced rhythmic contractions. Only glaucine and laudanosine inhibited K+-induced uterine contractions more than oxytocin-induced uterine contractions. In Ca+-free medium, sustained contractions induced by oxytocin or vanadate were relaxed by the alkaloids tested except for glaucine and laudanosine indicating no inhibitory effect on intracellular calcium release. Those alkaloids containing an unsaturated heterocyclic ring (papaverine, papaverinol, papaveraldine, N-methylpapaverine and dehydropapaverine) exhibited a more specific activity than those with a tetrahydroisoquinoline ring.

COMPOUND LIBRARIES

The present invention relates to compounds capable of binding to the active site of protein kinase enzymes. The invention further relates to libraries of compounds and a family of libraries of compounds for use in screening programmes against protein kinases as well as the individual compounds for use in hit to lead and lead optimisation projects, and similar stages in the drug discovery process. The invention also provides methods for making compounds and libraries.