68360-20-3Relevant academic research and scientific papers
The synthesis of precursor of FP- (+) DTBZ
Wu, Caijiao,Li, Hui,Sun, Feiyang,Bao, Changshun,Bao, Xuefei,Chen, Guoliang
, p. 3218 - 3225 (2019)
A synthetic route to the precursor of FP- (+) DTBZ was disclosed, in which 3-hydroxy-4-methoxybenzaldehyde was employed as a starting material. In the method, the benzyl-protecting protocol and the in-situ Diels-Alder reaction made the procedure more practical because of the mild conditions for selectively deprotection and the accelerated reaction process.
Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D
Colligs, Vanessa,Hansen, Steven Peter,Imbri, Dennis,Seo, Ean-Jeong,Kadioglu, Onat,Efferth, Thomas,Opatz, Till
, p. 6137 - 6148 (2017/09/30)
A D-ring contracted analogue of the strongly cytotoxic marine pyrrole alkaloid lamellarin D was synthesized and investigated for its antiproliferative action towards a wild type and a multidrug resistant (MDR) cancer cell line. The compound was found to inhibit tumor cell growth at submicromolar concentrations and showed a lower relative resistance in the MDR cell line than the antitumor drug camptothecin to which lamellarin D shows cross resistance and with which lamellarin D shares the same binding site.
A SYNTHETIC APPROACH TO (+/-)-O-METHYLCLAVIZEPINE: AN ALTERNATIVE SYNTHESIS OF C-NORCULARINE
Hara, Hiroshi,Kishigami, Masanori,Endoh, Masaki,Kaneko, Ken-ichi,Hoshino, Osamu
, p. 219 - 228 (2007/10/02)
C-Norcularine (2) was synthesized stepwise via the xanthone (3) or by intramolecular Pictet-Spengler reaction directly from the amino aldehyde (10).
