686343-39-5

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 135284-85-4 7-oxo-hept-2-ynoic acid methyl ester 
• 66120-16-9 methyl 7-mesylhept-2-enoate 
• 22977-45-3 methyl 7-chloro-3-oxoheptanoate 
• 882872-52-8 2,2-dimethyl-5-(5-chloropentanoyl)-1,3-dioxan-4,6-dione 
• 882872-58-4 1-[(1S)-phenylethyl]-2-[(methoxycarbonyl)methyliden]piperidine 
• 1119-46-6 5-chloro-valeric acid 

Downstream Products

• 171730-95-3 methyl (R)-(2-piperidino)acetate 

Relevant academic research and scientific papers

Practical method for the synthesis of (R)-homopipecolinic acid and (R)-homoproline esters from ω-chloroalkanoic acids and available chiral amines

A practical synthesis of (R)-homopipecolinic acid methyl ester 1 and (R)-homoproline methyl ester 2 was performed utilizing (i) a direct intramolecular cyclization of ω-chloro-β-enamino esters 11 and 12, which were prepared from available (S)-1-phenylethy

Convenient multigram synthesis of (R)-homopipecolic acid methyl ester

(R)-Homopipecolic acid methyl ester has been prepared on a multigram scale from 3,4-dihydro-2H-pyran in five steps and 36% overall yield. The stereochemistry was introduced via an asymmetric Michael addition and a fractional crystallization. Georg Thieme

Novel Routes to Chiral 2-Alkoxy-5-/6-methoxycarbonylmethylidenepyrrolidines/-piperidines

We report the results of a study aimed at the diastereoselective synthesis of chiral 2-alkoxy-5-/6-methoxy carbonylmethylidenepyrrolidines/-piperidines by condensation of chiral amines onto ω-oxo alkynoates and ω-oxo β-keto esters.