686723-63-7Relevant academic research and scientific papers
Photocatalytic α-Tertiary Amine Synthesis via C?H Alkylation of Unmasked Primary Amines
Alder, Catherine M.,Ballantyne, George,Cresswell, Alexander J.,Cunningham, William B.,Edwards, Lee J.,Grayson, Matthew N.,Kinsella, Anna G.,McKay, Blandine S. J.,Mules, Tom,Ryder, Alison S. H.,Turner-Dore, Jacob
, p. 14986 - 14991 (2020/06/20)
A practical, catalytic entry to α,α,α-trisubstituted (α-tertiary) primary amines by C?H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report a simple and scalable solution to this problem that does not require any in situ protection of the amino group and proceeds with 100 percent atom-economy. Our strategy, which uses an organic photocatalyst in combination with azide ion as a hydrogen atom transfer (HAT) catalyst, provides a direct synthesis of α-tertiary amines, or their corresponding γ-lactams. We anticipate that this methodology will inspire new retrosynthetic disconnections for substituted amine derivatives in organic synthesis, and particularly for challenging α-tertiary primary amines.
ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
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Paragraph 00363, (2016/04/20)
Described herein are compounds of Formula (S-I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
Radical Carboazidation: Expedient Assembly of the Core Structure of Various Alkaloid Families
Panchaud, Philippe,Ollivier, Cyril,Renaud, Philippe,Zigmantas, Sarunas
, p. 2755 - 2759 (2007/10/03)
A procedure for one-pot intermolecular radical addition of 2-iodoesters to terminal alkenes followed by azidation of the radical adduct has been developed. This sequential reaction represents an alkene carboazidation process. Its efficacy is demonstrated
A new synthetic entry to the tricyclic skeleton of FR901483 by palladium-catalyzed cyclization of vinyl bromides with ketone enolates
Bonjoch, Josep,Diaba, Fa?za,Puigbó, Gemma,Peidró, Emma,Solé, Daniel
, p. 8387 - 8390 (2007/10/03)
A new synthetic entry to the FR901483 core is described. The Pd-mediated cyclization of amino-tethered vinyl halides and ketone enolates from the azaspiro[4.5]decan-8-ones 5 and 10 gives the functionalized 7,10a-methanoperhydropyrrolo[1,2-a]azocines 1 and 11, respectively.
N-methoxy-N-acylnitrenium ions: Application to the formal synthesis of (±)-desmethylamino FR901483
Wardrop, Duncan J.,Zhang, Wenming
, p. 2353 - 2356 (2007/10/03)
(matrix presented) The formal synthesis of (±)-desmethylamino FR901483 (2) is described. Construction of the unique azatricyclic skeleton of 2 was accomplished by a sequence which involved (i) preparation of dienone 7 by an N-methoxy-N-acylnitrenium ion-i
