6912-63-6

Basic information

• Product Name: 1-Sedrin
• Synonyms: 1-Hydroxy-2-methylamino-1-phenylpropane;(1R,2S)-2-(Methylamino)-1-phenylpropan-1-ol;(-)-alpha-(1-Methylaminoethyl)benzyl alcohol;Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaR)-;Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (-)-;alpha-Hydroxy-beta-methyl amine propylbenzene;Ephedrine;2-Methylamino-1-phenyl-1-propanol;1-Phenyl-2-methylaminopropanol;Ephedremal;1-Phenyl-1-hydroxy-2-methylaminopropane
• CAS NO: 6912-63-6
• Molecular Formula: C10H15NO
• Molecular Weight: 165.2322
• EINECS: 206-080-5
• Mol File: 6912-63-6.mol
• Article Data: 82

Chemical Properties

• Boiling Point: 255 °C at 760 mmHg
• Flash Point: 85.6 °C
• Appearance: white crystals or powder
• Density: 1.015 g/cm³
• CAS DataBase Reference: 1-Sedrin(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Sedrin(6912-63-6)
• EPA Substance Registry System: 1-Sedrin(6912-63-6)

Safety Data

• Hazardous Substances Data: 6912-63-6(Hazardous Substances Data)

Usage

General Description

1-Sedrin is a medication that contains the active ingredients acetaminophen, caffeine, and codeine phosphate. Acetaminophen is a pain reliever and fever reducer, while caffeine acts as a stimulant and enhances the effects of the other ingredients. Codeine phosphate is an opioid analgesic that works by changing the way the brain and nervous system respond to pain. 1-Sedrin is commonly used to treat moderate to severe pain and discomfort, such as headaches, dental pain, and muscle aches. It is important to use 1-Sedrin only as directed by a healthcare professional, as misuse or overdose can lead to serious health complications.

Upstream product

• 5650-44-2 methcathinone 
• 90-63-1 (RS)-1-hydroxy-1-phenylpropan-2-one 
• 74-89-5 methylamine 
• 93-55-0 1-phenyl-propan-1-one 
• 50-00-0 formaldehyd 
• 492-41-1 (1R,2S)-norephedrine 
• 90-82-4 pseudoephedrine 
• 127-09-3 sodium acetate 
• 94133-42-3 (+)-Chloroephedine hydrochloride 
• 82222-50-2 N-(1,2-diphenylethylamino)ephedrine 
• 64868-20-8 (1S,2R)-(1-methyl-2-phenyl-2-hydroxy)ethyltrimethylammonium iodide 
• 2799-16-8 (2R)-hydroxypropylamine 
• 16735-30-1 (S)-2-(benzyl-methyl-amino)-1-phenyl-propan-1-one 
• 123367-02-2 (S)-2-(2,5-Dimethyl-pyrrol-1-yl)-1-phenyl-propan-1-ol 

Downstream Products

• 110195-71-6 ((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-((Ξ)-β-hydroxy-phenethyl)-methyl-amine 
• 100608-88-6 3ξ-[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-acrylaldehyde 
• 113750-46-2 (+/-)-3,4r-dimethyl-2ξ-octyl-5c-phenyl-oxazolidine 
• 100389-11-5 (+/-)-2ξ-dichloromethyl-3,4r-dimethyl-5c-phenyl-oxazolidine 
• 101778-30-7 (+/-)-2ξ-heptyl-3,4r-dimethyl-5c-phenyl-oxazolidine 
• 91049-48-8 (4R,5S)-3,4-dimethyl-5-phenyloxazolidin-2-one 
• 123055-93-6 6-((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-6-methyl-6,7-dihydro-5H-dibenz[c,e]azepinium; bromide 
• 112532-00-0 (1S,2R)-(-)-ephedrinium (S)-(+)-mandelate 
• 494846-57-0 (-)-trans-(1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 124226-71-7 6-methyl-9,10-didehydro-ergoline-8β-carboxylic acid-[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide] 
• 103397-84-8 bis-((1Ξ,2S)-2-methylamino-1-phenyl-propyl)-ether 
• 6402-25-1 L-erythro-2-methylamino-1-(4-amino-phenyl)-propanol-⁽¹⁾ 
• 42511-08-0 (+)-hexahydro-pseudoephedrine 
• 36298-43-8 3,4-dimethyl-2,5-diphenyl-oxazolidine 

Relevant articles and documents

Resolution of Racemic Amines with 2-Methyl-2-phenylbutanedioic Acid

Five racemic amines were resolved in high chemical and optical yields using (S)-(+)-2-methyl-2-phenylbutanedioic acid as resolving reagent.The reagent can be recovered quantitatively and without any change in its optical purity. (R)-(-)-2-Methyl-2-phenylbutanedioic acid was also obtained.

BIOCATALYTICAL PROCESS FOR RACEMIZATION OF D-EPHEDRINE

This invention relates to methods for racemization of dextro-rotatory ephedrine via enzymatic kinetic conversion, and is particularly useful for conversion of dextro- rotatory ephedrine (d- ephedrine) to racemic mixture of dextro-rotatory ephedrine (d-ephedrine) and levo-rotatory ephedrine (l-ephedrine) to recover the levo-rotatory ephedrine that exhibit potential bronchodilatory and anti-hypotensive activities. The process provides a suspension of Rhizopus Oryzae fungi pellets in diammonium phosphate buffer having pH in the range of pH 5 to 9 and effective sonication to extract specific enzymes for inversion of functional groups present on the chiral carbon atom of d-ephedrine molecule at low temperature which has advantages of working at lower temperature range (20 to 50 °C), lower energy consumption, lesser formation of by-products.

Evaluation of the Edman degradation product of vancomycin bonded to core-shell particles as a new HPLC chiral stationary phase

A modified macrocyclic glycopeptide-based chiral stationary phase (CSP), prepared via Edman degradation of vancomycin, was evaluated as a chiral selector for the first time. Its applicability was compared with other macrocyclic glycopeptide-based CSPs: TeicoShell and VancoShell. In addition, another modified macrocyclic glycopeptide-based CSP, NicoShell, was further examined. Initial evaluation was focused on the complementary behavior with these glycopeptides. A screening procedure was used based on previous work for the enantiomeric separation of 50 chiral compounds including amino acids, pesticides, stimulants, and a variety of pharmaceuticals. Fast and efficient chiral separations resulted by using superficially porous (core-shell) particle supports. Overall, the vancomycin Edman degradation product (EDP) resembled TeicoShell with high enantioselectivity for acidic compounds in the polar ionic mode. The simultaneous enantiomeric separation of 5 racemic profens using liquid chromatography-mass spectrometry with EDP was performed in approximately 3?minutes. Other highlights include simultaneous liquid chromatography separations of rac-amphetamine and rac-methamphetamine with VancoShell, rac-pseudoephedrine and rac-ephedrine with NicoShell, and rac-dichlorprop and rac-haloxyfop with TeicoShell.