6914-73-4

Basic information

• Product Name: 1-CYANO-CYCLOPROPANECARBOXYLIC ACIDMETHYL ESTER
• Synonyms: 1-CYANO-CYCLOPROPANECARBOXYLIC ACIDMETHYL ESTER;Cyclopropanecarboxylic acid, 1-cyano-, methyl ester (7CI,8CI,9CI);methyl 1-cyanocyclopropanecarboxylate;1-cyanocyclopropanecarboxylate
• CAS NO: 6914-73-4
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.12528
• EINECS: 604-604-1
• Product Categories: ACIDHALIDE
• Mol File: 6914-73-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 205.8°C at 760 mmHg
• Flash Point: 85.3°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.246mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-CYANO-CYCLOPROPANECARBOXYLIC ACIDMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYANO-CYCLOPROPANECARBOXYLIC ACIDMETHYL ESTER(6914-73-4)
• EPA Substance Registry System: 1-CYANO-CYCLOPROPANECARBOXYLIC ACIDMETHYL ESTER(6914-73-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6914-73-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 7, p. 559, 1977 DOI: 10.1080/00397917709409277

InChI:InChI=1/C6H7NO2/c1-9-5(8)6(4-7)2-3-6/h2-3H2,1H3

Upstream product

• 6914-79-0 1-cyano-cyclopropanecarboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 107-06-2 1,2-dichloro-ethane 
• 105-34-0 methyl 2-cyanoacetate 
• 106-93-4 ethylene dibromide 

Downstream Products

• 98730-77-9 1-hydroxymethyl-cyclopropanecarbonitrile 
• 6914-74-5 1-aminocarbonylcyclopropanecarboxylic acid 
• 6914-79-0 1-cyano-cyclopropanecarboxylic acid 
• 204376-48-7 1-(<<(tert-butoxy)carbonyl>amino>methyl)cyclopropane-1-carboxylic acid 
• 930298-98-9 1-(4-methoxylphenyl)-2-oxo-3-pyrrolidinecarbonitrile 
• 930298-97-8 1-(4-methylphenyl)-2-oxo-3-pyrrolidinecarbonitrile 
• 930298-96-7 2-oxo-1-phenyl-3-pyrrolidinecarbonitrile 
• 914226-26-9 1-aminomethyl-cyclopropanecarboxylic acid methyl ester 

Relevant articles and documents

BTK Inhibitors and uses thereof

The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.

Palladium(II)-Catalyzed highly enantioselective C-H arylation of cyclopropylmethylamines

C-H arylation via a Pd(II)/Pd(IV) catalytic cycle has been one of the most extensively studied C-H activation reactions since the 1990s. Despite the rapid development of this reaction in the past two decades, an enantioselective version has not been reported to date. Herein, we report a Pd(II)-catalyzed highly enantioselective (up to 99.5% ee) arylation of cyclopropyl C-H bonds with aryl iodides using mono-N-protected amino acid (MPAA) ligands, providing a new route for the preparation of chiral cis-aryl-cyclopropylmethylamines. The enantiocontrol is also shown to override the diastereoselectivity of chiral substrates.

NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVE AND A PRODUCTION METHOD FOR SAME

The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).