6933-26-2

Basic information

• Product Name: TICARCILLIN IMPURITY A
• Synonyms: TICARCILLIN IMPURITY A;(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[[(thiophen-3-yl)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;Decarboxyticarcillin;decarboxytiaprofenic acid
• CAS NO: 6933-26-2
• Molecular Formula: C₁₃H₁₂OS
• Molecular Weight: 216.29878
• Mol File: 6933-26-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 199-200 °C(Press: 13 Torr)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• CAS DataBase Reference: TICARCILLIN IMPURITY A(CAS DataBase Reference)
• NIST Chemistry Reference: TICARCILLIN IMPURITY A(6933-26-2)
• EPA Substance Registry System: TICARCILLIN IMPURITY A(6933-26-2)

Safety Data

• Hazardous Substances Data: 6933-26-2(Hazardous Substances Data)

Usage

Definition

ChEBI: A thiophene substituted at C-2 by benzoyl and at C-4 by an ethyl group.

Upstream product

• 64964-17-6 5-Ethyl-2-thiophencarbonsaeurechlorid 
• 38111-44-3 phenylzinc(II) bromide 
• 67-56-1 methanol 
• 33005-95-7 tiaprofenic acid 
• 23229-72-3 5-ethyl-2-thiophenecarboxylic acid 
• 88-15-3 2-Acetylthiophene 
• 872-55-9 2-ethylthiophene 
• 98-88-4 benzoyl chloride 

Downstream Products

• 3958-03-0 Tetrabromothiophene 
• 143381-62-8 [5-(1-Methoxy-ethyl)-thiophen-2-yl]-phenyl-methanone 
• 143379-91-3 2-Benzoyl-5-(1-hydroxyethyl)thiophene 
• 128-38-1 4,4'-dihydroxy-3,3',5,5'-tetra-tert-butylbiphenyl 
• 207126-39-4 1,2-bis(5-ethyl-2-thienyl)-1,2-diphenylethane-1,2-diol 
• 546-24-7 Pummerer ketone 
• 10568-14-6 4-methyl-2-(4-methylphenoxy)phenol 
• 15519-73-0 2,2'-Dihydroxy-4,4'-dimethylbiphenyl 

Relevant articles and documents

Time-resolved spectroscopic study of the photochemistry of tiaprofenic acid in a neutral phosphate buffered aqueous solution from femtoseconds to final products

The photo-decarboxylation and overall reaction mechanism of tiaprofenic acid (TPA) was investigated by femtosecond transient absorption (fs-TA), nanosecond transient absorption (ns-TA), and nanosecond time-resolved resonance Raman (ns-TR3) spec

Mechanism of lipid peroxidation photosensitized by tiaprofenic acid: Product studies using linoleic acid and 1,4-Cyclohexadienes as model substrates

A careful study of the linoleic acid hydroperoxide (LOOH) profile obtained upon peroxidation of linoleic acid (LA) photosensitized by tiaprofenic acid (TPA) and analogous ketones has been undertaken to distinguish between type-I and type-II photoperoxidation mechanisms. 1,4-Cyclohexadiene and 1,2-dimethylcyclohexa-2,5-diene-carboxylic acid (CHDCA) have also been used as models for LA since they also have double allylic systems. Coir-radiation of LA with TPA and decarboxytiaprofenic acid (DTPA) in acetonitrile and micellar media produced significant amounts of conjugated dienic LOOH. The cis,trans to trans,trans ratio depended on the irradiation time; thus, this parameter is an ambiguous tool for mechanistic assignment. An interesting finding was the decrease of the LOOH level after long irradiation times in mixtures photooxidized by DTPA, which is attributed to quenching of the DTPA triplet by the generated dienic LOOH. High-performance liquid chromatography analyses confirmed that the main pathway operating in photodynamic lipid peroxidation sensitized by (D)TPA is a type-I mechanism. However, product studies using CHDCA have clearly shown that a type-II mechanism is also operating and might contribute to the overall photooxidation process in a significant way.

Photochemistry of tiaprofenic acid, a nonsteroidal anti-inflammatory drug with phototoxic side effects

The phototoxic nonsteroidal anti-inflammatory drug tiaprofenic acid (1) is photolabile under aerobic conditions. Irradiation of a methanol solution of 1 under oxygen produces the photoproducts 2, 3, 4, and 5, and also produces a singlet oxygen as evidenced by trapping with 2,5-dimethylfuran.