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15519-73-0

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15519-73-0 Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 3248, 1994 DOI: 10.1021/jo00091a003Tetrahedron Letters, 33, p. 2207, 1992 DOI: 10.1016/0040-4039(92)88178-8

Check Digit Verification of cas no

The CAS Registry Mumber 15519-73-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,5,1 and 9 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 15519-73:
(7*1)+(6*5)+(5*5)+(4*1)+(3*9)+(2*7)+(1*3)=110
110 % 10 = 0
So 15519-73-0 is a valid CAS Registry Number.

15519-73-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-hydroxy-5-methylphenyl)-4-methylphenol

1.2 Other means of identification

Product number -
Other names 2,2'-dihydroxy-5,5'-dimethyldiphenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15519-73-0 SDS

15519-73-0Relevant articles and documents

Development of the radical C–O coupling reaction of phenols toward the synthesis of natural products comprising a diaryl ether skeleton

Tanaka, Kumpei,Gotoh, Hiroaki

, p. 3875 - 3885 (2019/06/18)

Compounds comprising a diaryl ether skeleton exist among natural phenols. The diaryl ether skeleton is thought to be biosynthesized through the coupling of two or more phenols. It is an important structural feature in medicines and agrochemicals, and it is imperative to develop methods for constructing such skeletons in organic synthesis. However, by the synthesis method through the coupling of phenols, coupling occurs preferentially at the ortho-substituted carbon atom of phenols. In this study, various radical-generating reagents and conditions were investigated with the aim of developing a short-step construction method of the diaryl ether skeleton by the radical homo-coupling of two phenol molecules. In addition, cross-coupling reactions between radicals of 2,4,6-tri-tert-butylphenol and p-substituted phenol were conducted to synthesize eight C (ortho)–O coupling products. Based on the results, a computational chemical approach was employed to verify the cause of C (ortho)–O bond formation.

Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions

Jiang, Jian-An,Chen, Cheng,Huang, Jian-Gang,Liu, Hong-Wei,Cao, Song,Ji, Ya-Fei

supporting information, p. 1248 - 1254 (2014/03/21)

A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcohols and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds. The ligand- and additive-free Cu(OAc)2-catalyzed atmospheric oxidation mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodology is expected to be of significant value for both fundamental research and practical applications.

Isolation of cross-coupling products in model studies on the photochemical modification of proteins by tiaprofenic acid

Miranda, Miguel Angel,Perez-Prieto, Julia,Lahoz, Agustin,Morera, Isabel M.,Sarabia, Zaideth,Martinez-Manez, Ramon,Castell, Jose V.

, p. 497 - 502 (2007/10/03)

To gain insight into the chemical nature of drug-induced photoallergy, model studies have been carried out on the photochemical modification of proteins by tiaprofenic acid. Irradiation of decarboxylated tiaprofenic acid (DTPA) in the presence of p-cresol leads to C-C- and C-O-connected p-cresol 'dimers', together with DTPA hydrodimers. The p-cresol-DTPA cross-coupling product was not detected in this reaction. However, a product of this type is formed using a more hindered phenol, such as 2,6-di-tert-butylphenol. Similar results are obtained when tiaprofenic acid (TPA) or its methyl ester are used as photosensitizers. The observed formation of 'dimers' can be related to protein photo-crosslinking, through the coupling of two tyrosine units. On the other hand, phenol-(D)TPA cross-coupling may be relevant to the understanding of drug-protein photobinding.

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