6937-34-4

Usage

Uses

Used in Analytical Chemistry:
3-IODOPHTHALIC ACID is used as a chelating agent for the interaction with uranyl ions. The application reason is to study the interaction between uranyl ions and 3-IODOPHTHALIC ACID using the Calvin-Bjerrum titration technique. This technique helps in understanding the complex formation and stability constants of the uranyl-3-IODOPHTHALIC ACID complex, which can be useful in various analytical and environmental applications.

InChI:InChI=1/C8H5IO4/c9-5-3-1-2-4(7(10)11)6(5)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 58142-99-7 5-iodoisoquinoline 
• 5434-20-8 3-aminophthalic acid 
• 31599-60-7 1-iodo-2,3-dimethylbenzene 
• 603-11-2 3-nitrophthalic acid 
• 85-44-9 phthalic anhydride 
• 62351-80-8 diethyl-3-aminobenzene-1,2-dicarboxylate 
• 24564-71-4 3-Nitrophthaloyl dichloride 
• 34529-06-1 dimethyl 3-aminophthalate 
• 13365-26-9 dimethyl 3-nitrophthalate 
• 102928-38-1 dimethyl 3-iodophthalate 
• 67193-50-4 3-iodo-phthalic acid diethyl ester 

Downstream Products

• 28418-88-4 3-iodophthalic anhydride 
• 4842-02-8 3-Jod-phthalsaeure-bis-(3-methoxy-butylester) 
• 426832-99-7 mIBX 
• 1073137-42-4 ethyl 2-(3-hydroxy-1-oxo-4-phenyl-1H-indene-2-carboxamido)acetate 
• 37418-88-5 3-hydroxyphthalic anhydride 
• 866639-19-2 3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-o-carbamoylbenzoic acid 

Relevant academic research and scientific papers

Synthesis, insecticidal activities and SAR of novel phthalamides targeting calcium channel

In order to find novel and environmental friendly insecticides targeting the ryanodine receptor, three series of novel phthalamides containing heptafluoroisopropyl group, low fluorine atoms group and non-fluorine group were designed and synthesized. 35 novel structures of three series were obtained. Insecticidal activities of title compounds against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that most of title compounds showed moderate to high activities at the tested concentration. The structure-activity relationship (SAR) was discussed in detail. During synthesizing title compounds B8, C7, D1, D9 and D12, their corresponding positional isomers (B8′, C7′, D1′, D9′ and D12′) were afforded, and their structures were confirmed by 2D NMR. The calcium-imaging technique was also applied to investigate the effects of compounds B2, B10, C4 and C5 on the intracellular calcium ion concentration ([Ca2+]i), which indicated that they released stored calcium ions from endoplasmic reticulum, which denoted that some compounds are potential modulators of the insect ryanodine receptor (RyR).

New thalidomide analogues derived through Sonogashira or Suzuki reactions and their TNF expression inhibition profiles

A library of new thalidomide C4/5 analogues containing either a phenyl or alkyne tether were synthesized using Sonogashira or Suzuki cross coupling reactions from their aryl halogenated precursors. All thalidomide analogues were tested for their ability to inhibit the expression of the proinflammatory cytokine Tumor Necrosis Factor (TNF). More explicitly the use of a novel reporter system utilizing the promoter region of the TNF gene in a human T-cell line provided a rapid and effective measure of NFκB transcriptional activity. Several compounds either containing either an aryl-isobutyl or aryl-isopropoxy group were the most effective in inhibiting TNF expression, and were several times more active than thalidomide itself. Five of the more active derivatives indicated an apoptotic response while one of these compounds, containing an aldehyde tether, showed possible influence of cell cycling effects.

JAK INHIBITOR

A JAK inhibitor comprising, as an active ingredient, a nitrogen-containing heterocyclic compound represented by formula (I) {wherein W represents a nitrogen atom or -CH-; X represents -C (=O) - or -CHR4- (wherein R4 represents a hydrogen atom, or the like); R1 represents the formula described below [wherein Q1 represents-CR8-(wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); Q2 represents -NR15- (wherein R15 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); and R5 and R6 may be the same or different and each represents a hydrogen atom, halogen, carboxy, substituted or unsubstituted lower alkyl, or the like], or the like; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof.

Synthesis and TNF expression inhibitory properties of new thalidomide analogues derived via Heck cross coupling

A library of new thalidomide analogues containing an olefin functionality were synthesised using a Heck cross coupling reaction from their aryl halogenated precursor. All analogues were tested for their ability to inhibit the synthesis of the proinflammatory cytokine Tumour Necrosis Factor (TNF). Compounds 22, 29, 33 and 37 were the most effective in this assay inhibiting TNF expression 50%, 69%, 52% and 50%, respectively. Crown Copyright

User- and eco-friendly hypervalent iodine reagent and method of synthesis

The present invention is a user- and eco-friendly hypervalent iodine reagent (mIBX) capable of selectively oxidizing allylic and benzylic alcohols in water and other eco-friendly solvents and having generally the following structure: 1Allylic and benzylic alcohols are cleanly oxidized to the corresponding carbonyl compounds in water or water-THF mixtures, or other mixtures, using a water-soluble o-iodoxybenzoic acid derivative of the present invention.

Synthesis and oxidation reactions of a user- and eco-friendly hypervalent iodine reagent

Allylic and benzylic alcohols are cleanly oxidized to the corresponding carbonyl compounds in water or water-THF mixtures using a water-soluble derivative of o-iodoxybenzoic acid. A mechanism involving single electron transfer steps is proposed for this facile and eco-friendly oxidation protocol.

On the regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides

A problem of 3-methoxyphthalide reduction by metal hydrides was reinvestigated. Various effects controlling selectivity of reductions in 3-substituted phthalides were studied, and a qualitative interpretation of the results is now proposed. Methods for obtaining enhanced yields of one or the other lactonic product were developed.