6937-34-4

Basic information

• Product Name: 3-IODOPHTHALIC ACID
• Synonyms: 3-IODOPHTHALIC ACID;3-Iodobenzene-1,2-dicarboxylic acid;3-Iodo-1,2-benzenedicarboxylic acid;NSC 42518;3-Iodophthaltc acid;3-Lodophthalic acid
• CAS NO: 6937-34-4
• Molecular Formula: C₈H₅IO₄
• Molecular Weight: 292.03
• Product Categories: Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Carboxylic Acids;Phenyls & Phenyl-Het;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 6937-34-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 232℃
• Boiling Point: 426.3 °C at 760 mmHg
• Flash Point: 211.6 °C
• Appearance: /
• Density: 2.138 g/cm³
• Vapor Pressure: 5.01E-08mmHg at 25°C
• Refractive Index: 1.704
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.91±0.10(Predicted)
• CAS DataBase Reference: 3-IODOPHTHALIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODOPHTHALIC ACID(6937-34-4)
• EPA Substance Registry System: 3-IODOPHTHALIC ACID(6937-34-4)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 6937-34-4(Hazardous Substances Data)

Usage

Uses

The study of the interaction of uranyl ion with 3-Iodophthalic Acid by Calvin-Bjerrum titration technique.

InChI:InChI=1/C8H5IO4/c9-5-3-1-2-4(7(10)11)6(5)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 58142-99-7 5-iodoisoquinoline 
• 5434-20-8 3-aminophthalic acid 
• 31599-60-7 1-iodo-2,3-dimethylbenzene 
• 85-44-9 phthalic anhydride 
• 62351-80-8 diethyl-3-aminobenzene-1,2-dicarboxylate 
• 24564-71-4 3-Nitrophthaloyl dichloride 
• 34529-06-1 dimethyl 3-aminophthalate 
• 603-11-2 3-nitrophthalic acid 
• 13365-26-9 dimethyl 3-nitrophthalate 
• 102928-38-1 dimethyl 3-iodophthalate 
• 67193-50-4 3-iodo-phthalic acid diethyl ester 

Downstream Products

• 4841-96-7 3-Jod-phthalsaeure-di-n-propylester 
• 105694-45-9 4-iodophthalide 
• 1073137-42-4 ethyl 2-(3-hydroxy-1-oxo-4-phenyl-1H-indene-2-carboxamido)acetate 
• 37418-88-5 3-hydroxyphthalic anhydride 
• 866639-19-2 3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-o-carbamoylbenzoic acid 

Relevant articles and documents

Synthesis, insecticidal activities and SAR of novel phthalamides targeting calcium channel

In order to find novel and environmental friendly insecticides targeting the ryanodine receptor, three series of novel phthalamides containing heptafluoroisopropyl group, low fluorine atoms group and non-fluorine group were designed and synthesized. 35 novel structures of three series were obtained. Insecticidal activities of title compounds against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that most of title compounds showed moderate to high activities at the tested concentration. The structure-activity relationship (SAR) was discussed in detail. During synthesizing title compounds B8, C7, D1, D9 and D12, their corresponding positional isomers (B8′, C7′, D1′, D9′ and D12′) were afforded, and their structures were confirmed by 2D NMR. The calcium-imaging technique was also applied to investigate the effects of compounds B2, B10, C4 and C5 on the intracellular calcium ion concentration ([Ca2+]i), which indicated that they released stored calcium ions from endoplasmic reticulum, which denoted that some compounds are potential modulators of the insect ryanodine receptor (RyR).

JAK INHIBITOR

A JAK inhibitor comprising, as an active ingredient, a nitrogen-containing heterocyclic compound represented by formula (I) {wherein W represents a nitrogen atom or -CH-; X represents -C (=O) - or -CHR4- (wherein R4 represents a hydrogen atom, or the like); R1 represents the formula described below [wherein Q1 represents-CR8-(wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); Q2 represents -NR15- (wherein R15 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); and R5 and R6 may be the same or different and each represents a hydrogen atom, halogen, carboxy, substituted or unsubstituted lower alkyl, or the like], or the like; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof.

User- and eco-friendly hypervalent iodine reagent and method of synthesis

The present invention is a user- and eco-friendly hypervalent iodine reagent (mIBX) capable of selectively oxidizing allylic and benzylic alcohols in water and other eco-friendly solvents and having generally the following structure: 1Allylic and benzylic alcohols are cleanly oxidized to the corresponding carbonyl compounds in water or water-THF mixtures, or other mixtures, using a water-soluble o-iodoxybenzoic acid derivative of the present invention.