693775-75-6Relevant academic research and scientific papers
Copper-catalyzed hydrocarboxylation of alkynes using carbon dioxide and hydrosilanes
Fujihara, Tetsuaki,Xu, Tinghua,Semba, Kazuhiko,Terao, Jun,Tsuji, Yasushi
supporting information; experimental part, p. 523 - 527 (2011/03/16)
Getting a fix: The copper-catalyzed hydrocarboxylation of alkynes using carbon dioxide in the presence of a hydrosilane, which serves as a reducing agent, has been developed (see scheme). Copper fluorides bearing N-heterocyclic carbene ligands such as IMes and Cl2IPr show high catalytic activities.
Iron(III) chloride catalyzed oxidative coupling of aromatic nuclei (Joc The Journal of Organic Chemistry (2004) 6 (913-916))
Wang, Kailiang,Lue, Maoyun,Zhu, Xiaoqing,Wang, Qingmin
supporting information; experimental part, p. 935 - 938 (2009/06/20)
Easily available and nontoxic FeCl3 catalyzes. intramolecular oxidative coupling for the direct construction of the phenan- threne ring using meta-chloroperbenzoic acid as sole oxidant at room temperature in excellent yields. The mechanistic investigations show that FeCl3-catalyzed coupling proceeds through the heterolytic coupling (A+ + B). The catalytic approach has been applied to intermolecular biaryl coupling of 2-naphthols and phenol ether.
Up to 96% enantioselectivities in the hydrogenation of fluorine substituted (E)-2,3-diphenylpropenoic acids over cinchonidine-modified palladium catalyst
Szollosi, Gyoergy,Herman, Beata,Felfoeldi, Karoly,Fueloep, Ferenc,Bartok, Mihaly
supporting information; experimental part, p. 2804 - 2814 (2009/10/20)
The enantioselective hydrogenation of methoxy-and fluorine-substituted (E)-2,3-diphenylpropenoic acid derivatives was studied over cinchonidine- modified, supported palladium catalysts in the absence and presence of benzylamine as additive. The fluorine substituent in the appropriate position was even more efficient than the methoxy group in increasing the optical purity of the saturated product. High enantioselectivities, up to 96%, were obtained in the hydrogenation of some disubstituted derivatives, unprecedented in the hydrogenation of prochiral unsaturated carboxylic acids over modified heterogeneous catalyst. The best optical purities were reached in the hydrogenation of derivates bearing a para-substituent on the β phenyl and an ortho-substituent on the a phenyl ring, respectively. The influence of the substituent on the β phenyl ring was attributed to the increase in the efficiency of the modifier-substrate interaction by electronic effects or to a decrease in the adsorption strength of the substituted acid over modified surface sites. The beneficial effect of the ortho-substituent on the a phenyl ring was assumed to be due to the additional interaction of this substituent with the modifier on the surface, its steric hindrance contributing only in a small part to the observed effect. These suggestions were supported by results obtained in the hydrogenations of some methyl-substituted derivatives.
Discovery of Diarylacrylonitriles as a Novel Series of Small Molecule Sortase A Inhibitors
Oh, Ki-Bong,Kim, Soo-Hwan,Lee, Jaekwang,Cho, Won-Jea,Lee, Taeho,Kim, Sanghee
, p. 2418 - 2421 (2007/10/03)
On the basis of a hit from random screening, a novel class of small-molecule sortase A inhibitors was generated. The primary structure-activity relationship and the minimal structural requirements for potency were established through structural modifications and molecular modeling studies.
