63785-34-2

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 95549-10-3 (4-Dimethylamino-phenylsulfanyl)-(4-methoxy-phenyl)-acetonitrile 
• 104-47-2 p-methoxybenzylnitrile 
• 5432-07-5 (Z)-3-(4-methoxyphenyl)-2-phenylacrylonitrile 
• 140-29-4 phenylacetonitrile 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 77287-34-4 formamide 

Downstream Products

• 72035-46-2 2,3-bis(4-methoxyphenyl)propanenitrile 
• 207730-75-4 (2Z)-2,3-bis(4-hydroxyphenyl)prop-2-enenitrile 
• 170238-94-5 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 219670-51-6 (Z)-2,3-bis(4-methoxyphenyl)acrylaldehyde 
• 1346463-52-2 4,5-bis(4-methoxyphenyl)penta-(2E,4Z)-dienoyl azide 
• 1346463-39-5 4,5-bis(4-methoxyphenyl)penta-(2E,4Z)-dienoic acid 
• 693775-75-6 (Z)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester 
• 32383-66-7 (Z)-2,3-bis(4-methoxyphenyl)acrylic acid 
• 53629-05-3 2,3-Bis(p-methoxyphenyl)propionitril-<2-D> 
• 107276-25-5 2,3-bis-(4-methoxy-phenyl)-propylamine 

Relevant academic research and scientific papers

Synthesis of an estrogen receptor β-selective radioligand: 5-[ 18F]fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl) pentanenitrile and comparison of in vivo distribution with 16α-[ 18F]fluoro-17β-estradiol

Estrogen receptor β (ERβ), a less active ER subtype that appears to have a restraining effect on the more active ERα, could be a factor that determines the level of estrogen action in certain estrogen target tissues. ERβ is found in breast cancer, and its

Accelerated Discovery of α-Cyanodiarylethene Photoswitches

Cyanodiarylethene chromophores are able to undergo constitutional exchange via dynamic covalent chemistry (DCC). During this process, the central ethylene bridge of the molecular scaffold can be broken and thereby enables the assembly of a new combination of aryl moieties around the reformed ethylene bridge. The reversible CC double bond exchange has exemplarily been investigated using α-cyanostilbenes. Establishing a dynamic equilibrium reaction from α-cyanodiarylethene with arylacetonitriles under mild conditions has been the basis to access constitutional libraries of new photoswitches with potentially improved properties. When subject to irradiation with light of adequate wavelength, α-cyanodiarylethenes undergo Z/E isomerization followed by ring-closure. By screening the thus accessible dynamic chromophore libraries using a desired detection wavelength, we could identify specific dithienyl analogues that exhibit three-state photochromism. The combination of dynamic constitutional libraries of functional chromophores in combination with the light-guided screening and selection should lead to more rapid exploration of structural diversity dye chemistry.

Ni-Mediated Generation of "cN" Unit from Formamide and Its Catalysis in the Cyanation Reactions

The in situ generation of a "cyano" unit from readily available organic precursors is of high interest in synthetic chemistry. Herein, we report the first example of Ni-mediated dehydration of formamide to form "CN" and its subsequent catalytic applications in the hydrocyanation of alkynes and cyanation of aryl halides. Formamide can serve as a convenient source for the nitrile unit, in that it releases water as the only byproduct.

Substituent effect on the solid-state photoinduced luminescence of α-cyanostilbene derivatives

Summary: A series of α-cyanostilbene derivatives with aggregation-induced enhanced emission （ AIEE ） was obtained. All the compounds were characterized by UV?vis spectroscopy, fluorescence and nuclear magnetic resonance. These compounds exhibited blue, gr

Facile Preparation of α-Cyano-α,ω-Diaryloligovinylenes: A New Class of Color-Tunable Solid Emitters

An efficient Knoevenagel condensation reaction was used to construct a series of α-cyano-α,ω-diaryloligovinylenes, which show prominent fluorescence emission in the solid state. On investigating the effect of conjugation length on fluorescent properties,

Substituent effects on the iodine-catalyzed thermal cyclization of 3,4-diphenylbuta-1,3-dienyl isocyanates: Mechanistic studies

The thermal cyclization of 3,4-diphenylbuta-1,3-dienyl isocyanates 1, generated in situ from the corresponding azides, was investigated using iodine as a catalyst. Diphenylpyridinones 2, phenylnaphthalenes 3, and indenes 4 were produced via intramolecular ring closure. The nature of the substituents on the phenyl rings was found to be crucial to the distribution of cyclized products 2 - 4. The mechanism of the reaction is also discussed.

Synthesis, characterisation and photophysical properties of a,a-diaryl-acrylonitrile derivatives

a,b-Diarylacrylonitrile derivatives can be prepared by two different routes: (1) the intermolecular condensation of the same arylacetonitriles (2) the condensation of arylaldehydes and arylacetonitriles with a catalytic amount of NaOCH3 at room temperature. Several a,b-diarylacrylonitrile derivatives have been synthesised in this paper and characterised. The UV-vis absorption and photoluminescent (PL) spectra of the products were investigated.

Solvent-free condensation of phenylacetonitrile and nonanenitrile with 4-methoxybenzaldehyde: Optimization and mechanistic studies

The condensation of phenylacctonitrile with 4-methoxybenzaldehyde can he carried out by two solvent-free methods: i) using neat powdered KOH at room temperature with equivalent amounts of aldehyde, nitrile and base for 3 min, and ii) using K2CO3 in the presence of a phase transfer agent for 3 min under microwave activation or conventional heating. By extending the reaction time up to 10 min, four different products were obtained from phenyl or nitrile group migration. With nonanenitrile, only the second method could be applied to give two kinds of condensed compounds with or without phenyl (or nitrile) group migration. The intervention of non-thermal MW-specific effects was proved in some cases and interpreted. The Royal Society of Chemistry 2005.

Solvent-free condensation of arylacetonitrile with aldehydes

The condensation of a series of arylacetonitriles with aldehydes can be carried out by mixing equivalent amounts of reagents with neat powdered KOH at room temperature for 3-60 min depending on the aldehyde steric hindrance. At higher temperature (110°C), yields were generally higher and purity increased within very short reaction times (1-5 min). With pentamethylphenylacetonitrile, a phase transfer agent was necessary to give a satisfactory yield.

Discovery of Diarylacrylonitriles as a Novel Series of Small Molecule Sortase A Inhibitors

On the basis of a hit from random screening, a novel class of small-molecule sortase A inhibitors was generated. The primary structure-activity relationship and the minimal structural requirements for potency were established through structural modifications and molecular modeling studies.