69397-93-9

Basic information

• Product Name: 5-METHOXY-N-METHYL-2-NITROBENZENAMINE
• Synonyms: 5-METHOXY-N-METHYL-2-NITROBENZAMINE;5-METHOXY-N-METHYL-2-NITROBENZENAMINE;5-Methoxy-N-methyl-2-nitroaniline;5-Methoxy-N-methyl-2-nitrobenzenamine95%;5-METHOXY-N-METHYL-2-NITROBENZENAMINE 95%;5-Methoxy-N-methyl-3-nitrobenzenamine
• CAS NO: 69397-93-9
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.18
• Mol File: 69397-93-9.mol

Chemical Properties

• Boiling Point: 346.3°C at 760 mmHg
• Flash Point: 163.3°C
• Appearance: /
• Density: 1.258g/cm³
• Vapor Pressure: 5.8E-05mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 5-METHOXY-N-METHYL-2-NITROBENZENAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-N-METHYL-2-NITROBENZENAMINE(69397-93-9)
• EPA Substance Registry System: 5-METHOXY-N-METHYL-2-NITROBENZENAMINE(69397-93-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 69397-93-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
5-METHOXY-N-METHYL-2-NITROBENZENAMINE is used as a research chemical for studying its psychoactive properties and potential hallucinogenic effects. It aids in understanding the mechanisms of action and potential therapeutic applications in the field of psychopharmacology.
Used in Drug Development:
In the pharmaceutical industry, 5-METHOXY-N-METHYL-2-NITROBENZENAMINE is used as a starting material or intermediate in the synthesis of new drugs with potential therapeutic benefits. Its unique molecular structure and psychoactive properties make it a valuable compound for drug discovery and development.
Used in Forensic Toxicology:
5-METHOXY-N-METHYL-2-NITROBENZENAMINE is used as a reference compound in forensic toxicology for the identification and analysis of designer drugs and new psychoactive substances. Its detection and characterization are crucial for understanding the prevalence and risks associated with these substances.
Used in Analytical Chemistry:
In analytical chemistry, 5-METHOXY-N-METHYL-2-NITROBENZENAMINE is used as a standard or reference material for the development and validation of analytical methods for the detection and quantification of amphetamine-like compounds in various matrices, such as biological samples and environmental samples.
Used in Toxicological Studies:
5-METHOXY-N-METHYL-2-NITROBENZENAMINE is used in toxicological studies to investigate its potential toxic effects, mechanism of action, and safety profile. This information is essential for assessing the risks associated with its use and for guiding the development of safe and effective therapeutic agents.

InChI:InChI=1/C8H10N2O3/c1-9-7-5-6(13-2)3-4-8(7)10(11)12/h3-5,9H,1-2H3

Upstream product

• 109643-21-2 toluene-4-sulfonic acid-(5-methoxy-N-methyl-2-nitro-anilide) 
• 28987-59-9 3-chloro-4-nitroanisole 
• 74-89-5 methylamine 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 
• 35966-84-8 4-chloro-2-methylaminonitrobenzene 
• 1635-61-6 5-chloro-2-nitroaniline 
• 185428-59-5 N-(5-methoxy-2-nitrophenyl)-N-methylcarbamic acid t-butyl ester 
• 611-06-3 2,4-dichloronitrobenzene 
• 124-41-4 sodium methylate 
• 20628-18-6 1-acetamido-5-methoxy-2nitrobenzene 
• 74-88-4 methyl iodide 
• 1579830-78-6 C₃₅H₅₂N₂O₅ 
• 1579830-23-1 C₂₀H₃₂N₂O₄ 
• 16133-49-6 5-methoxy-2-nitroaniline 

Downstream Products

• 55783-47-6 4-methoxy-N²-methyl-benzene-1,2-diamine; dihydrochloride 
• 129139-48-6 5-methoxy-N-methyl-1,2-phenylenediamine 
• 123855-75-4 7-Methoxy-1-methylquinoxaline-2,3(1H,4H)-dione 
• 1139689-70-5 4,4'-methanediylbis(5-methoxy-N-methyl-2-nitroaniline) 
• 1579830-08-2 C₂₅H₄₂N₂O₄ 
• 1579830-23-1 C₂₀H₃₂N₂O₄ 
• 1579830-48-0 C₃₅H₅₀N₂O₅ 
• 1579830-78-6 C₃₅H₅₂N₂O₅ 
• 945023-35-8 6-methoxy-1-methyl-1H-benzo[d]imidazol-2-amine 
• 3360-78-9 4-methoxy-N-methyl-1,2-phenylenediamine 
• 50591-23-6 1-methyl-1H-benzo[d]imidazol-6-ol 
• 10394-42-0 6-methoxy-1-methylbenzimidazole 

Relevant articles and documents

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A photocleavable masked nuclear-receptor ligand enables temporal control of C.elegans development

The development and lifespan of C.elegans are controlled by the nuclear hormone receptor DAF-12, an important model for the vertebrate vitaminD and liverX receptors. As with its mammalian homologues, DAF-12 function is regulated by bile acid-like steroidal ligands; however, tools for investigating their biosynthesis and function invivo are lacking. A flexible synthesis for DAF-12 ligands and masked ligand derivatives that enable precise temporal control of DAF-12 function was developed. For ligand masking, photocleavable amides of 5-methoxy-N-methyl-2-nitroaniline (MMNA) were introduced. MMNA-masked ligands are bioavailable and after incorporation into the worm, brief UV irradiation can be used to trigger the expression of DAF-12 target genes and initiate development from dauer larvae into adults. The invivo release of DAF-12 ligands and other small-molecule signals by using photocleavable MMNA-masked ligands will enable functional studies with precise spatial and temporal resolution. Copyright

Luminescent bimetallic lanthanide bioprobes for cellular imaging with excitation in the visible-light range

A series of homoditopic ligands H2LCX (X=4-6) has been designed to self-assemble with lanthanide ions (LnIII), resulting in neutral bimetallic helicates of overall composition [Ln 2(LCX)3] with the aim of testing the influence of substituents on the photophysical properties, particularly the excitation wavelength. The complex species are thermodynamically stable in water (logβ23 in the range 26-28 at pH 7.4) and display a metal-ion environment with pseudo-D3 symmetry and devoid of coordinated water molecules. The emission of EuIII, TbIII and Yb III is sensitised to various extents, depending on the properties of the ligand donor levels. The best helicate is [Eu2(L C5)3] with excitation maxima at 350 and 365 nm and a quantum yield of 9%. The viability of cervix cancer HeLa cells is unaffected when incubated with up to 500 μm of the chelate during 24 h. The helicate permeates into the cells by endocytosis and locates into lysosomes, which co-localise with the endoplasmatic reticulum, as demonstrated by counterstaining experiments. The relatively long excitation wavelength allows easy recording of bright luminescent images on a confocal microscope (μcxc = 405 nm). The new lanthanide bioprobe remains undissociated in the cell medium, and is amenable to facile derivatisation. Examination of data for seven Eu III and TbIII bimetallic helicates point to shortcomings in the phenomenological rules of thumb between the energy gap ΔE( 3ππ*-5DJ) and the sensitisation efficiency of the ligands.

Novel Enantiomeric Pure Beta Agonists, Manufacturing and Use as a Medicament Thereof

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