6941-28-2

Usage

InChI:InChI=1/C9H7NO2S/c1-5-10-7-3-2-6(9(11)12)4-8(7)13-5/h2-4H,1H3,(H,11,12)

Upstream product

• 42474-60-2 2-methylbenzo[d]thiazole-6-carbonitrile 
• 108-24-7 acetic anhydride 
• 1571-66-0 4-amino-3-mercaptobenzoic acid hydrochloride 
• 14543-45-4 4-amino-3-mercaptobenzoic acid 
• 62-55-5 thioacetamide 
• 3622-35-3 benzothiazole-6-carboxylic acid 
• 74-88-4 methyl iodide 
• 190071-23-9 4-(acetylamino)-3-iodo-benzoic acid methyl ester 

Downstream Products

• 20061-51-2 6-Formyl-2-methyl-benzthiazol 
• 20077-92-3 2-methylbenzothiazol-5-yl methyl ketone 
• 101117-74-2 N-benzoyl-N'-(2-methyl-benzothiazole-6-carbonyl)-hydrazine 
• 99358-50-6 2-methyl-benzothiazole-6-carboxylic acid hydrazide 

Relevant academic research and scientific papers

NOVEL JNK INHIBITORS

Disclosed are substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines and imidazo[1,2-d]triazines compounds of the formula: (1.0) Also disclosed are methods for treating JNK1 and ERK mediated diseases using the compounds of formula 1.0.

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.

Condensation of thioamides with 2-aminothiophenols: A versatile synthesis of benzothiazoles

Thioamides condense with 2-aminothiophenols under convenient and mild conditions to provide a variety of simple and functionalized benzothiazoles in fair to good yields.