69519-09-1

Basic information

• Product Name: 1,3,2-Dioxaborolane, 2-(4-chlorophenyl)-
• CAS NO: 69519-09-1
• Molecular Formula: C8H8BClO2
• Molecular Weight: 182.414
• Mol File: 69519-09-1.mol

Chemical Properties

• CAS DataBase Reference: 1,3,2-Dioxaborolane, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,2-Dioxaborolane, 2-(4-chlorophenyl)-(69519-09-1)
• EPA Substance Registry System: 1,3,2-Dioxaborolane, 2-(4-chlorophenyl)-(69519-09-1)

Safety Data

• Hazardous Substances Data: 69519-09-1(Hazardous Substances Data)

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 107-21-1 ethylene glycol 

Downstream Products

• 5739-37-7 4'-chloro-3-phenylpropiophenone 
• 871817-25-3 C₈H₈BClO 
• 2050-68-2 4,4'-dichlorobiphenyl 
• 43141-66-8 1-chloro-4-(difluoromethyl) benzene 
• 82525-17-5 5-(4-chlorophenyl)pyrimidine 
• 1250907-53-9 C₁₁H₁₁ClO₂ 
• 1250907-72-2 methyl (E)-4-(4-chlorophenyl)but-3-enoate 
• 1657-50-7 (E)-1-(4-chlorophenyl)-2-phenylethene 
• 18218-20-7 1-(4-chlorophenyl)-1-phenylethene 

Relevant articles and documents

Insight into Copper Catalysis: In Situ Formed Nano Cu2O in Suzuki-Miyaura Cross-Coupling of Aryl/Indolyl Boronates

A ligand-free copper catalyzed Suzuki-Miyaura coupling of 3,5-diiodopyridine with aryl and indole boronates has been explored in good to excellent yields. In situ generation of nano-Cu2O from CuCl2 under the reaction conditions has been discovered for the first time. The generality of the reaction was further demonstrated by the arylation of 5-iodopyrimidine, iodopyridines, iodobenzenes, and diiodobenzenes and resulted in good to moderate yields. Moreover, bisindole alkaloid Scalaridine A has been successfully synthesized in 60% overall yield.

Selective cine substitution of 1-arylethenyl acetates with arylboron reagents and a diene/rhodium catalyst

When the crowd says Bo: A carbon-carbon bond is selectively formed at the β position of 1- arylethenyl acetate when the alkenyl substrate is reacted with arylboronic acids in the presence of a cycloocta-1,5-diene/rhodium catalyst. The choice of the ligand is crucial for the unusual cine substitution. Copyright

Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use

Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

Compounds for the Treatment of Periodontal Disease

Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH

As bacteria continue to develop resistance toward current antibiotics, we find ourselves in a continual battle to identify new antibacterial agents and targets. We report herein a class of boron-containing compounds termed borinic esters that have broad spectrum antibacterial activity with minimum inhibitory concentrations (MIC) in the low microgram/mL range. These compounds were identified by screening for inhibitors against Caulobacter crescentus CcrM, an essential DNA methyltransferase from Gram negative α-proteobacteria. In addition, we demonstrate that borinic esters inhibit menaquinone methyltransferase in Gram positive bacteria using a new biochemical assay for MenH from Bacillus subtilis. Our data demonstrate the potential for further development of borinic esters as antibacterial agents as well as leads to explore more specific inhibitors against two essential bacterial enzymes.