55681-26-0

Upstream product

• 6425-12-3 1-phenyl-2,2-dimorpholin-1-yl-ethanone 
• 64-19-7 acetic acid 
• 78146-52-8 phenylglyoxal monohydrate 
• 100-66-3 methoxybenzene 
• 56074-65-8 bis-(4-methoxy-phenyl)-phenyl-acetaldehyde 
• 7664-93-9 sulfuric acid 
• 5465-47-4 1,2-bis-(4-methoxy-phenyl)-1-phenyl-ethane-1,2-diol 
• 623-12-1 4-chloromethoxybenzene 
• 98-86-2 acetophenone 
• 69545-37-5 di(p-anisyl)methyl bromide 
• 62573-86-8 N-benzoylbenzimidazole 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1218936-92-5 1-(4-methoxyphenyl)-2-oxo-2-phenylethyl dimethyl phosphate 

Downstream Products

• 859777-81-4 2,2-bis-(4-methoxy-phenyl)-1,1-diphenyl-ethanol 
• 872298-25-4 2,2-bis(4-methoxyphenyl)-1-phenylethan-1-ol 
• 726-18-1 4,4'-dianisylmethane 
• 65-85-0 benzoic acid 
• 90-96-0 bis(p-methoxyphenyl)methanone 

Relevant academic research and scientific papers

Aqueous α-Arylation of Mono- and Diarylethanone Enolates at Low Catalyst Loading

Acetophenone and deoxybenzoin derivatives are selectively α-arylated using a combination of very small amounts of palladium acetate and diphenylphosphine oxide as catalyst system and water as the only solvent. Target di- and triarylethanones are isolated virtually free of metal residues, and the reaction is amenable to gram-scale. A mechanistic proposal based on TEM images, poisoning experiments, kinetic plot and ESI-MS spectrometry is also provided. (Figure presented.).

Aerobic dehydrogenative α-diarylation of benzyl ketones with aromatics through carbon-carbon bond cleavage

Substituted benzyl ketones reacted with aromatics in the presence of K 2S2O8 in CF3COOH at room temperature, yielding α-diaryl benzyl ketones through a carbon-carbon bond cleavage. In the reaction, two new carbon-carbon bonds were formed and one carbon-carbon bond was cleaved. It is very interesting that two different nucleophiles such as benzyl ketones and aromatics were coupled together without metal, which is unusual in organic synthesis.

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Lewis acid-promoted friedel-crafts alkylation reactions with α-ketophosphate electrophiles

The BF3·OEt2-promoted nucleophilic substitution of α-aryl-α-ketophosphates to afford α,α-diaryl ketone products is described. Electron-rich α-ketophosphates perform best, with electron-neutral and electron-poor substrates also tolerated. The reaction is tolerant of a range of aromatic, heteroaromatic, and nonaromatic nucleophiles, with yields ranging from 44% to 84%. Enantioenriched starting material yields racemic product, suggesting an SN1 pathway via an acylcarbenium ion.

Palladium-catalyzed synthesis of diarylmethanes: Exploitation of carbanionic leaving groups

A novel route to the synthesis of diarylmethanes via a Pd-catalyzed α-arylation of benzyl ketones is rseported. By harnessing the inherent reactivity of enolates, it is possible to circumvent the need for a transmetalating reagent such as boron for the co

A highly practical and general route for α-arylations of ketones using bis-phosphinoferrocene-based palladium catalysts

Well-defined, air-stable Pd complexes of bis-phosphinoferrocene family of catalysts have been studied in the arylation of various ketones with aryl chlorides and aryl bromides. Bis(di-tert-butyl)phosphinoferrocene (DtBPF)-based catalysts such as (DtBPF) P

Reductive cross-coupling between N-acylbenzimidazoles and diarylketones promoted by Sm/TiCl4

The reductive cross-coupling reaction between N-acylbenzimidazoles and diarylketones promoted by Sm/TiCl4 was performed in refluxing THF under a nitrogen atmosphere, to give 1,2,2-triaryl ethanones in moderate to good yields.

α-arylation of ketones using highly active, air-stable (DtBPF)PdX2 (X = Cl, Br) catalysts

α-Arylation of various ketones with aryl chlorides and bromides using the well-defined and air-stable (DtBPF)PdX2 (X = Cl, Br) catalysts gave 80-100% yield of the coupled products under relatively mild conditions at low catalyst loadings. The X

PCP-Bis(phosphinite) pincer complexes: new homogeneous catalysts for α-arylation of ketones

Two new p-alkoxycarbonylated palladium bis(phosphinite) PCP pincer complexes are easily prepared and for the first time evaluated as homogeneous catalysts in α-arylation of ketone enolates. Apart from the total absence of phenyl-aryl exchange by-products and significantly low catalyst loadings, the general α-arylation protocols described in this letter feature not only a broad applicability to a range of ketones and aryl bromides with marked electronic and steric differences but also the possibility to generate mono-diarylated products.